USH1C Protein, Human (His-SUMO)

USH1C is an anchoring and scaffolding protein critical for cochlear hair cell mechanotransduction. It forms a network with USH1G, CDH23 and MYO7A and contributes to the development and maintenance of hair cell bundles. USH1C Protein, Human (His-SUMO) is the recombinant human-derived USH1C protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of USH1C Protein, Human (His-SUMO) is 533 a.a., with molecular weight of ~76.3 kDa.

USH1C, an anchoring and scaffolding protein, plays a crucial role in the mechanotransduction process within cochlear hair cells, forming an intricate network with USH1G, CDH23, and MYO7A. It is essential for the normal development and maintenance of cochlear hair cell bundles. As a component of the intermicrovillar adhesion complex (IMAC), USH1C contributes to brush border differentiation, exerting control over microvilli organization and length. Its regulatory significance is evident in the assembly of the complex, where it recruits CDHR2, CDHR5, and MYO7B to the tips of microvilli. USH1C participates in various complexes, including IMAC and the complex composed of USH1C, USH1G, and MYO7A. Its interactions extend to F-actin, USH2A, SLC4A7, USHBP1, CDH23, USH1G, MYO7B, CDHR2, CDHR5, and ANKS4B, emphasizing its multifaceted role in cellular processes and protein associations.

Human

E. coli

N-His;N-SUMO

Q9Y6N9-4(M1-F533)

10083  [NCBI]

MDRKVAREFRHKVDFLIENDAEKDYLYDVLRMYHQTMDVAVLVGDLKLVINEPSRLPLFDAIRPLIPLKHQVEYDQLTPRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEGRELFMTDRERLAEARQRELQRQELLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEEDWGSKEQLLLPKTITAEVHPVPLRKPKYDQGVEPELEPADDLDGGTEEQGEQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEAEAALQKAWNQGGDWIDLVVAVCPPKEYDDELTFF

Approximately 76.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.