VEGFR-2 Protein, Rat (HEK293, Fc)

VEGFR-2 Protein is a type III receptor tyrosine kinase, also known as the receptor for vascular endothelial growth factor 2.VEGFR-2 Protein mediates vascular endothelial growth factor (VEGF)-induced endothelial proliferation, survival, migration, tubular morphogenesis, and sprouting, and plays a key role in angiogenesis and vasculogenesis.VEGFR-2 Protein, Rat (HEK293, Fc) is the recombinant rat-derived VEGFR-2 protein, expressed by HEK293 , with C-hFc labeled tag.

VEGFR-2 protein mediates vascular endothelial growth factor (VEGF)-induced endothelial proliferation, survival, migration, tubular morphogenesis, and sprouting, and plays a key role in angiogenesis and vasculogenesis^[1][3].
The signal of VEGFR-2 protein is a survival mechanism in hippocampal neurons, which can prevent mitochondrial dysfunction and oxidative stress^[2].
VEGFR-2 Protein is highly expressed in the microvessels of diabetes and can be used as a biomarker for early diagnosis of diabetes retinopathy (DR) ^[4].
VEGFR-2 protein mediates hydrogen sulfide (H₂S)-induced dilation of rat basilar artery^[5].

Rat

HEK293

C-hFc

AAH87029.1 (M1-E760)

25589  [NCBI]

Approximately 110 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.