Kdr - kinase insert domain receptor Gene

Rattus norvegicus

Also known as Vegfr-2

Gene ID: 25589 | Gene type: protein coding

About Kdr

Primary_assembly 14: 32,217,871-32,261,018 forward strand.mRatBN7.2:CM026987.1

This gene has 2 transcripts (splice variants), 199 orthologues, 54 paralogues and is associated with 125 phenotypes. Biased expression in Lung (RPKM 646.5), Adrenal (RPKM 253.7) and 8 other tissues.

Summary

Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including generation of neurons; positive regulation of endothelial cell proliferation; and positive regulation of intracellular signal transduction. Located in several cellular components, including neuron projection; neuronal cell body; and plasma membrane. Used to study adhesions of uterus; brain ischemia; cystitis; and myocardial infarction. Biomarker of several diseases, including artery disease (multiple); impotence; ovarian hyperstimulation syndrome; prostate disease (multiple); and retinopathy of prematurity. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system Cancer (multiple); glioblastoma; macular degeneration (multiple); and pancreatic Cancer (multiple). Orthologous to human VEGFR2/KDR/Flk-1 (kinase insert domain receptor). [provided by Alliance of Genome Resources, Apr 2022]

Kdr Products(1)

mRNA	Protein	Name
NM_013062.2	NP_037194.2	vascular endothelial growth factor receptor 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables growth factor binding	IMP IMP: Inferred from mutant phenotype	9442048	RGD
enables growth factor binding	IPI IPI: Inferred from physical interaction	9160888	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10329451	RGD
enables vascular endothelial growth factor receptor activity	IMP IMP: Inferred from mutant phenotype	9442048	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in endochondral bone growth	IMP IMP: Inferred from mutant phenotype	14612527	RGD
involved in endothelial tube morphogenesis	IMP IMP: Inferred from mutant phenotype	25942475	RGD
involved in male gonad development	IDA IDA: Inferred from direct assay	16672722	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15780476	RGD
involved in negative regulation of systemic arterial blood pressure	IGI IGI: Inferred from genetic interaction	12052848	RGD
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	16329123	RGD
involved in positive regulation of TOR signaling	IMP IMP: Inferred from mutant phenotype	18221855	RGD
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	15951738	RGD
involved in positive regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	18221855	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17881084	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17881084	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	18221855	RGD
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17360578	RGD
involved in positive regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	18221855	RGD
involved in positive regulation of neurogenesis	IEP IEP: Inferred from expression pattern	15258583	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	18221855	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	9263985	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	20187850	RGD
involved in response to hypoxia	IMP IMP: Inferred from mutant phenotype	15780476	RGD
involved in response to oxygen levels	IEP IEP: Inferred from expression pattern	15885787	RGD
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	17360578	RGD
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9442048	RGD
involved in vasodilation	IGI IGI: Inferred from genetic interaction	12052848	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in neuronal cell body	IDA IDA: Inferred from direct assay	11934468	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Kdr Protein Structure

Ig_3

I-set

VEGFR-2_TMD

PTKc_VEGFR2

0
300
600
900
1200
1343 a.a.

Protein Preferred Names

Protein Names

vascular endothelial growth factor receptor 2

FLK-1	FLK1 kinase insert domain receptor (VEGF receptor 2)
FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)	fetal liver kinase 1
kinase insert domain protein receptor	protein-tyrosine kinase receptor flk-1

Recombinant Kdr Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73481	VEGFR-2 Protein, Rat (HEK293, Fc)	AAH87029.1 (M1-E760)	≥95%
HY-P74470	VEGFR-2 Protein, Rat (HEK293, His)	AAH87029 (A20-E760)	≥95%

Related Agents

Approval

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10260	Vandetanib		99.95%	Yes
HY-112306	Ripretinib		98.90%	Yes
HY-14914	Azilsartan		99.51%	Unkown
HY-10330	Toceranib	Inhibitor	96.86%	Unkown
HY-10330A	Toceranib phosphate	Inhibitor	98.54%	Unkown
HY-10260B	Vandetanib hydrochloride		/	Unkown
HY-10260A	Vandetanib trifluoroacetate		/	Unkown

Clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50751	Linifanib		99.28%	Phase 3
HY-10205	Cediranib		99.58%	Phase 3
HY-13314	Tesevatinib	Inhibitor	99.21%	Phase 3
HY-12018	Vatalanib dihydrochloride		99.91%	Phase 3
HY-13049	Cediranib maleate		99.95%	Phase 3
HY-10203	Vatalanib	Inhibitor	99.93%	Phase 3
HY-12018A	Vatalanib hydrochloride	Inhibitor	/	Phase 3
HY-50751G	Linifanib (GMP)	Inhibitor	/	Phase 3
HY-110272	Vatalanib succinate	Inhibitor	/	Phase 3
HY-10374	Semaxinib	Inhibitor	99.96%	Phase 2
HY-13024	Rebastinib		99.91%	Phase 2
HY-10338	Foretinib	Inhibitor	99.06%	Phase 2
HY-10987A	ENMD-2076		99.12%	Phase 2
HY-10987	ENMD-2076 Tartrate		99.42%	Phase 2
HY-10204	OSI-930		98.57%	Phase 1
HY-100315	XL 999	Inhibitor	99.34%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99830	Conbercept		/	Phase 4
HY-P99768	Olinvacimab	Inhibitor	95.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (37)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12299	WH-4-023	Inhibitor	99.75%	Unkown
HY-151361	AMPK-IN-3	Inhibitor	98.51%	Unkown
HY-W062835	CGP77675	Inhibitor	99.00%	Unkown
HY-13561	AZM475271	Inhibitor	99.85%	Unkown
HY-13838	PLX647	Inhibitor	99.79%	Unkown
HY-133551	WF-47-JS03	Inhibitor	99.63%	Unkown
HY-101219	VEGFR-IN-1	Inhibitor	98.42%	Unkown
HY-132135	(1E)-CFI-400437 dihydrochloride	Inhibitor	98.08%	Unkown
HY-15769	WHI-P180	Inhibitor	99.62%	Unkown
HY-18302	c-Kit-IN-5-1	Inhibitor	98.16%	Unkown
HY-125741	GW768505A free base	Inhibitor	98.66%	Unkown
HY-10517A	(Z)-Orantinib	Inhibitor	99.44%	Unkown
HY-13785	ZM 306416	Inhibitor	99.80%	Unkown
HY-119757	Tyrphostin AG1433	Inhibitor	99.08%	Unkown
HY-15814	HG-7-85-01		99.94%	Unkown
HY-100824	PP2 Analog	Inhibitor	/	Unkown
HY-10260S	Vandetanib-d6		/	Unkown
HY-10260S1	Vandetanib-d4		/	Unkown
HY-10260S2	Vandetanib-13C6		/	Unkown
HY-120214	TAS05567	Inhibitor	/	Unkown
HY-13838A	PLX647 dihydrochloride	Inhibitor	/	Unkown
HY-14979	ML786	Inhibitor	/	Unkown
HY-14979A	ML786 dihydrochloride	Inhibitor	/	Unkown
HY-15334	CEP-5214	Inhibitor	/	Unkown
HY-168114	Multi-kinase inhibitor 3	Inhibitor	/	Unkown
HY-168115	Multi-kinase inhibitor 4	Inhibitor	/	Unkown
HY-18318	Takeda-6D	Inhibitor	/	Unkown
HY-RS07226	KDR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07227	Kdr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07228	Kdr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W062835A	CGP77675 hydrate	Inhibitor	/	Unkown
HY-10330S	Toceranib-d8	Inhibitor	/	Unkown
HY-110045	ZM-306416 hydrochloride	Inhibitor	/	Unkown
HY-119757A	Tyrphostin AG1433 hydrochloride	Inhibitor	/	Unkown
HY-149451	SYHA1815	Inhibitor	/	Unkown
HY-15769A	WHI-P180 hydrochloride	Inhibitor	/	Unkown
HY-101628	VEGFR-2-IN-9	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kdr	NCBI	NCBI:3791
Macaca fascicularis	Kdr	NCBI	NCBI:102136227
Macaca mulatta	Kdr	NCBI	NCBI:698293

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