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Refanezumab  (Synonyms: GSK249320)

Cat. No.: HY-P99403 Purity: 98.44%
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Refanezumab (GSK249320) is an IgG1-type humanized monoclonal antibody directed against myelin-associated glycoprotein (MAG). Refanezumab binds to MAG and blocks MAG-mediated inhibition of axonal regeneration. Refanezumab can cross the blood-brain barrier (BBB) in animal stroke models. Refanezumab has the potential for the enhancement of recovery of function poststroke.

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CAS No. : 1233953-61-1

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Description

Refanezumab (GSK249320) is an IgG1-type humanized monoclonal antibody directed against myelin-associated glycoprotein (MAG). Refanezumab binds to MAG and blocks MAG-mediated inhibition of axonal regeneration. Refanezumab can cross the blood-brain barrier (BBB) in animal stroke models. Refanezumab has the potential for the enhancement of recovery of function poststroke[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
In Vivo

Refanezumab (GSK249320; 10 mg/kg; IV; starting 24 hours post-stroke and continuing weekly for 6 more doses) shows larger increases in neuroscore and staircase test. Refanezumab by intravenous penetrates the lesion site and is associated with a small effect on functional outcomes when initiated 24 hours post-stroke[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats (weight 361g)[1]
Dosage: 10 mg/kg
Administration: IV; starting 24 hours post-stroke and continuing weekly for 6 more doses; starting seven days post-stroke and continuing weekly for 5 more doses
Result: Animals treated 24 hours post-stroke showed larger increases in neuroscore and staircase test as compared to controls, but animals treated 7 days post-stroke showed no significant behavioral benefit.
Clinical Trial
Molecular Weight

148280.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Refanezumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human MAG/Siglec-4a Protein (His Tag) can bind Refanezumab. The EC50 for this effect is 0.72 ng/mL.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Refanezumab1233953-61-1GSK249320GSK 249320GSK-249320OthersIgG1-typehumanizedmonoclonal antibodymyelin-associated glycoproteinMAGaxonal regenerationblood-brain barrierBBBstrokeInhibitorinhibitorinhibit

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