2. Membrane Transporter/Ion Channel Autophagy Neuronal Signaling
  3. Autophagy TRP Channel
  4. (rel)-ML-SI3

(rel)-ML-SI3  (Synonyms: trans-ML-SI3)

Cat. No.: HY-139426A Purity: 99.81%
SDS COA Handling Instructions

Molarity Calculator

(rel)-ML-SI3 is one of the active ingredients of ML-SI3 (HY-139426) (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 μM/28.5 μM), and a potent activator of TRPML2 (EC50=3.3 μM).

For research use only. We do not sell to patients.

(rel)-ML-SI3 Chemical Structure

(rel)-ML-SI3 Chemical Structure

CAS No. : 2108567-79-7

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
5 mg USD 90 In-stock
10 mg USD 150 In-stock
25 mg USD 250 In-stock
50 mg USD 450 In-stock
100 mg USD 750 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (rel)-ML-SI3:

(rel)-ML-SI3 Related Antibodies

Top Publications Citing Use of Products

View All TRP Channel Isoform Specific Products:

View All Isoforms
TRPC TRPM TRPV TRPA TRPML

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(rel)-ML-SI3 is one of the active ingredients of ML-SI3 (HY-139426) (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 μM/28.5 μM), and a potent activator of TRPML2 (EC50=3.3 μM)[1][2][3].

IC50 & Target

TRPML1

3.1 μM (IC50)

TRPML2

3.3 μM (EC50)

TRPML3

28.5 μM (IC50)

In Vitro


Table: Activation and inhibition of the three subtypes of TRPML by the ML-SI3-type compounds[3]

Product_Names Catalog_No EC50 for activation [μM] IC50 for inhibition [μM]
TRPML1 TRPML2 TRPML3 TRPML1 TRPML2 TRPML3
(rel)-ML-SI3 HY-139426A - 3.3±1.5 - 3.1±1.5 - 28.5±15.9
(cis)-ML-SI3 / - 9.4±2.7 29.0±4.1 18.5±1.9 - -
(1S,2S)-ML-SI3 HY-134819 - 2.7±1.4 10.8±0.5 5.9±1.7 - -
(1R,2R)-ML-SI3 HY-134819A - - - 1.6±0.7 2.3±1.1 12.5±7.6
Mean values ± SD of at least three independent experiments are shown. -: no effect.
ML-SI3 HY-139426 The mixtrue of (rel)-ML-SI3 and (cis)-ML-SI3

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(rel)-ML-SI3 Related Antibodies
Molecular Weight

429.58

Formula

C23H31N3O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(N[C@H]1[C@H](N2CCN(C3=C(C=CC=C3)OC)CC2)CCCC1)(C4=CC=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (116.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3279 mL 11.6393 mL 23.2786 mL
5 mM 0.4656 mL 2.3279 mL 4.6557 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.81%

SDS (393 KB)

COA (253 KB) HNMR (288 KB) LCMS (260 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3279 mL 11.6393 mL 23.2786 mL 58.1964 mL
5 mM 0.4656 mL 2.3279 mL 4.6557 mL 11.6393 mL
10 mM 0.2328 mL 1.1639 mL 2.3279 mL 5.8196 mL
15 mM 0.1552 mL 0.7760 mL 1.5519 mL 3.8798 mL
20 mM 0.1164 mL 0.5820 mL 1.1639 mL 2.9098 mL
25 mM 0.0931 mL 0.4656 mL 0.9311 mL 2.3279 mL
30 mM 0.0776 mL 0.3880 mL 0.7760 mL 1.9399 mL
40 mM 0.0582 mL 0.2910 mL 0.5820 mL 1.4549 mL
50 mM 0.0466 mL 0.2328 mL 0.4656 mL 1.1639 mL
60 mM 0.0388 mL 0.1940 mL 0.3880 mL 0.9699 mL
80 mM 0.0291 mL 0.1455 mL 0.2910 mL 0.7275 mL
100 mM 0.0233 mL 0.1164 mL 0.2328 mL 0.5820 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

(rel)-ML-SI3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(rel)-ML-SI32108567-79-7trans-ML-SI3AutophagyTRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
(rel)-ML-SI3
Cat. No.:
HY-139426A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.