Remacemide hydrochloride  (Synonyms: FPL 12924AA)

Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na⁺ channel, is a weak uncompetitive NMDA receptor antagonist with IC₅₀s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively^[1]. Remacemide hydrochloride is an anticonvulsant agent^[2].

IC50: 68-76 μM (NMDA receptor)^[1]
IC50:160.6 μM(sodium channel)^[2]

Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na⁺ channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC₅₀ value of 160.6 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

304.81

C₁₇H₂₁ClN₂O

111686-79-4

NCC(NC(C)(C1=CC=CC=C1)CC2=CC=CC=C2)=O.[H]Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. G C Palmer, et al. Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann N Y Acad Sci. 1995 Sep 15;765:236-47; discussion 248.  [Content Brief]

  [2]. Sarah Santangeli, et al. Na⁺ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur J Pharmacol. 2002 Mar 1;438(1-2):63-8.  [Content Brief]

  [3]. L K M Wright, et al. Behavioral effects associated with chronic ketamine or remacemide exposure in rats. Neurotoxicol Teratol. May-Jun 2007;29(3):348-59.  [Content Brief]