2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Remacemide

Remacemide  (Synonyms: FPL 12924; PR 934-423; FPL 13592)

Cat. No.: HY-160604
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Remacemide (FPL 12924) is an orally active, non-competitive, low-affinity NMDA receptor antagonist. Remacemide shows neuroprotection activity in animal models of hypoxia and ischemic stroke. Remacemide is also an anticonvulsant, and can be used in Parkinson's disease and Huntington's disease research.

For research use only. We do not sell to patients.

Remacemide Chemical Structure

Remacemide Chemical Structure

CAS No. : 128298-28-2

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Other Forms of Remacemide:

Remacemide Related Antibodies

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description

Remacemide (FPL 12924) is an orally active, non-competitive, low-affinity NMDA receptor antagonist. Remacemide shows neuroprotection activity in animal models of hypoxia and ischemic stroke. Remacemide is also an anticonvulsant, and can be used in Parkinson's disease and Huntington's disease research[1][2][3][4].

IC50 & Target[1]

NMDA Receptor

 

Molecular Weight

268.35

Formula

C17H20N2O
CAS No.
SMILES

O=C(CN)NC(C)(CC1=CC=CC=C1)C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 87.5 mg/mL (326.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7265 mL 18.6324 mL 37.2648 mL
5 mM 0.7453 mL 3.7265 mL 7.4530 mL
View the Complete Stock Solution Preparation Table

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7265 mL 18.6324 mL 37.2648 mL 93.1619 mL
5 mM 0.7453 mL 3.7265 mL 7.4530 mL 18.6324 mL
10 mM 0.3726 mL 1.8632 mL 3.7265 mL 9.3162 mL
15 mM 0.2484 mL 1.2422 mL 2.4843 mL 6.2108 mL
20 mM 0.1863 mL 0.9316 mL 1.8632 mL 4.6581 mL
25 mM 0.1491 mL 0.7453 mL 1.4906 mL 3.7265 mL
30 mM 0.1242 mL 0.6211 mL 1.2422 mL 3.1054 mL
40 mM 0.0932 mL 0.4658 mL 0.9316 mL 2.3290 mL
50 mM 0.0745 mL 0.3726 mL 0.7453 mL 1.8632 mL
60 mM 0.0621 mL 0.3105 mL 0.6211 mL 1.5527 mL
80 mM 0.0466 mL 0.2329 mL 0.4658 mL 1.1645 mL
100 mM 0.0373 mL 0.1863 mL 0.3726 mL 0.9316 mL
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Remacemide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Remacemide128298-28-2FPL 12924 PR 934-423 FPL 13592FPL12924FPL-12924FPL13592FPL 13592FPL-13592iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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