2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Resolvin E1

Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production.

For research use only. We do not sell to patients.

Resolvin E1 Chemical Structure

Resolvin E1 Chemical Structure

CAS No. : 552830-51-0

Size Price Stock Quantity
Solvent
10 μg (285.3 μM * 100 μL in Ethanol) USD 370 In-stock
Solvent
25 μg (285.3 μM * 250 μL in Ethanol) USD 740 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Resolvin E1:

Resolvin E1 Related Antibodies

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1 Publications Citing Use of MCE Resolvin E1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

Resolvin E1 (0.1-100 nM) gives concentration-dependent inhibition of TNF-α–induced NF-κB activation with an EC50 of ～1.0 nM in ChemR23-transfected cells. Resolvin E1 (100 nM) increases phosphorylation of extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase both in peripheral blood monocytes and HEK-ChemR23 cells[2]. Resolvin E1 specifically interacts with the LTB4 receptor BLT1 on neutrophils and ChemR23 on monocytes to regulate leukocytes during inflammation. Resolvin E1 also stimulates the uptake and clearance of local cytokine[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Resolvin E1 Related Antibodies
In Vivo

Resolvin E1 (1.0 μg per mouse; 50 μg/kg; i.p.; on days -8, -1, and 0) protects mice from TNBS (2,4,6-trinitrobenzene sulfonic acid) colitis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6- to 8-week-old female BALB/c mice (TNBS colitis model)[1]
Dosage: 1.0 μg per mouse; 50 μg/kg
Administration: i.p.; on days -8, -1, and 0 before the induction of colitis
Result: Reduced overall mortality, which was 25% and 62.5% at 1.0 μg per mouse and 50 μg/kg, respectively.
Molecular Weight

350.45

Formula

C20H30O5
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CC[C@@H](O)/C=C/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (142.67 mM; Need ultrasonic and warming)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (239 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.8535 mL 14.2674 mL 28.5347 mL 71.3369 mL
5 mM 0.5707 mL 2.8535 mL 5.7069 mL 14.2674 mL
10 mM 0.2853 mL 1.4267 mL 2.8535 mL 7.1337 mL
15 mM 0.1902 mL 0.9512 mL 1.9023 mL 4.7558 mL
20 mM 0.1427 mL 0.7134 mL 1.4267 mL 3.5668 mL
25 mM 0.1141 mL 0.5707 mL 1.1414 mL 2.8535 mL
30 mM 0.0951 mL 0.4756 mL 0.9512 mL 2.3779 mL
40 mM 0.0713 mL 0.3567 mL 0.7134 mL 1.7834 mL
50 mM 0.0571 mL 0.2853 mL 0.5707 mL 1.4267 mL
60 mM 0.0476 mL 0.2378 mL 0.4756 mL 1.1889 mL
80 mM 0.0357 mL 0.1783 mL 0.3567 mL 0.8917 mL
100 mM 0.0285 mL 0.1427 mL 0.2853 mL 0.7134 mL
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Resolvin E1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Resolvin E1552830-51-0RvE1Resolvin E 1Resolvin E-1RvE 1RvE-1Endogenous Metaboliteendogenousmediatorinflammationcell-cellinteractionspolymorphonuclearleukocyteTNBScolitisInhibitorinhibitorinhibit

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