2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. Resomelagon acetate

Resomelagon acetate  (Synonyms: AP1189 acetate)

Cat. No.: HY-147301A Purity: 99.75%
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Resomelagon (AP1189) acetate is a potent, orally active melanocortin receptor (MR) agonist about MC1 and MC3. Resomelagon acetate induces ERK1/2 phosphorylation and Ca2+ mobilization. Resomelagon acetate has anti-inflammatory activity. Resomelagon acetate can be used for obesity and chronic inflammation research.

For research use only. We do not sell to patients.

Resomelagon acetate Chemical Structure

Resomelagon acetate Chemical Structure

CAS No. : 1809420-72-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Resomelagon acetate:

Resomelagon acetate Related Antibodies

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MC1R MC3R MC2R MC4R MC5R

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Description

Resomelagon (AP1189) acetate is a potent, orally active melanocortin receptor (MR) agonist about MC1 and MC3. Resomelagon acetate induces ERK1/2 phosphorylation and Ca2+ mobilization. Resomelagon acetate has anti-inflammatory activity. Resomelagon acetate can be used for obesity and chronic inflammation research[1][2].

IC50 & Target

Targrt: MC1 and MC3[1]
In Vitro

Resomelagon acetate (0-1000 μM; 8 min; HEK293A cells) promotes melanocortin signal transduction through ERK1/2 phosphorylation and Ca2+ mobilization[1].
Resomelagon acetate (1 nM; 30 min; peritoneal macrophages) has anti-inflammatory activity and inhibits TNF-α release and efferocytosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Resomelagon acetate Related Antibodies
In Vivo

Resomelagon acetate (0-10 mg/kg; i.p., i.v. and p.o.; for 24 h; male C57BL/6J wild-type (WT) and BALB/c mice) promotes resolution of acute inflammation in vivo[1].
Resomelagon acetate (25-50 mg/kg; p.o.; daily, for 8 d; male C57BL/6J wild-type (WT) and BALB/c mice) reduces arthritis in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

358.35

Formula

C16H18N6O4
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

N=C(N)N/N=C/C=C/C1=CC=CN1C2=C(C=CC=C2)[N+]([O-])=O.CC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (279.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7906 mL 13.9528 mL 27.9057 mL
5 mM 0.5581 mL 2.7906 mL 5.5811 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7906 mL 13.9528 mL 27.9057 mL 69.7642 mL
5 mM 0.5581 mL 2.7906 mL 5.5811 mL 13.9528 mL
10 mM 0.2791 mL 1.3953 mL 2.7906 mL 6.9764 mL
15 mM 0.1860 mL 0.9302 mL 1.8604 mL 4.6509 mL
20 mM 0.1395 mL 0.6976 mL 1.3953 mL 3.4882 mL
25 mM 0.1116 mL 0.5581 mL 1.1162 mL 2.7906 mL
30 mM 0.0930 mL 0.4651 mL 0.9302 mL 2.3255 mL
40 mM 0.0698 mL 0.3488 mL 0.6976 mL 1.7441 mL
50 mM 0.0558 mL 0.2791 mL 0.5581 mL 1.3953 mL
60 mM 0.0465 mL 0.2325 mL 0.4651 mL 1.1627 mL
80 mM 0.0349 mL 0.1744 mL 0.3488 mL 0.8721 mL
100 mM 0.0279 mL 0.1395 mL 0.2791 mL 0.6976 mL
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Resomelagon acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Resomelagon1809420-72-1AP1189AP 1189AP-1189Melanocortin ReceptorMC ReceptorERK1/2 phosphorylationCa2+anti-inflammatoryobesitychronic inflammationInhibitorinhibitorinhibit

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