RET-IN-21

Cat. No.: HY-148742 Purity: 97.00%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

RET-IN-21 is an inhibitor of receptor tyrosine kinase (RET), with the IC⁵⁰ of 4.4 μM, that has antitumor activity.

For research use only. We do not sell to patients.

RET-IN-21 Chemical Structure

CAS No. : 2414373-42-3

Size	Price	Stock	Quantity
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 390	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

RET-IN-21 is an inhibitor of receptor tyrosine kinase (RET), with the IC⁵⁰ of 4.4 μM, that has antitumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	4.4 μM Compound: 5	Inhibition of RET V804M mutant (unknown origin)expressed in human BaF3 cells assessed as reduction in cell viability incubated for 48 hrs by celltiter glo luminescence cell viability assay Inhibition of RET V804M mutant (unknown origin)expressed in human BaF3 cells assessed as reduction in cell viability incubated for 48 hrs by celltiter glo luminescence cell viability assay	[PMID: 32292556]

Molecular Weight

344.37

Formula

C₁₉H₁₆N₆O

CAS No.

2414373-42-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N)C1=CC=C(C2=C3N=C(NCC4=CC=NC=C4)C=CN3N=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (362.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9039 mL	14.5193 mL	29.0385 mL
5 mM	0.5808 mL	2.9039 mL	5.8077 mL
10 mM	0.2904 mL	1.4519 mL	2.9039 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.00%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (251 KB) HNMR (254 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Rebecca Newton, et al. Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase. ACS Med. Chem. Lett. 2020, 11, 4, 497–505

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9039 mL	14.5193 mL	29.0385 mL	72.5963 mL
	5 mM	0.5808 mL	2.9039 mL	5.8077 mL	14.5193 mL
	10 mM	0.2904 mL	1.4519 mL	2.9039 mL	7.2596 mL
	15 mM	0.1936 mL	0.9680 mL	1.9359 mL	4.8398 mL
	20 mM	0.1452 mL	0.7260 mL	1.4519 mL	3.6298 mL
	25 mM	0.1162 mL	0.5808 mL	1.1615 mL	2.9039 mL
	30 mM	0.0968 mL	0.4840 mL	0.9680 mL	2.4199 mL
	40 mM	0.0726 mL	0.3630 mL	0.7260 mL	1.8149 mL
	50 mM	0.0581 mL	0.2904 mL	0.5808 mL	1.4519 mL
	60 mM	0.0484 mL	0.2420 mL	0.4840 mL	1.2099 mL
	80 mM	0.0363 mL	0.1815 mL	0.3630 mL	0.9075 mL
	100 mM	0.0290 mL	0.1452 mL	0.2904 mL	0.7260 mL

RET-IN-21 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RET-IN-212414373-42-3RETRET InhibitorCancerInhibitorinhibitorinhibit

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