Reverse T3  (Synonyms: 3′,5′,3-Triiodothyronine)

Reverse T3 is a thyroid hormone that can be generated by deiodination of the prohormone thyroxine^[1]. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes^[2].

Reverse T3 (0.1 μM, 72 h) promotes cell proliferation in islet β-cell lines (rRINm5F and hCM)^[3].
Reverse T3 (0.1 μM) inhibits the apoptotic process in rRINm5F and hCM cells induced by Streptozocin (HY-13753) (15 mM for 2 h), S-Nitroso-N-Acetylpenicylamine (SNAP) (200 μM for 24 h), and H₂O₂ (50 μM, 30 min)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Reverse T3 (0-10 mg/kg, diet for 60 days) increases growth rate (SGR) and better food conversion ratio (FCR) in carp in comparison to the control group^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

650.97

C₁₅H₁₂I₃NO₄

5817-39-0

Solid

Off-white to yellow

IC(C=C(C=C1)C[C@H](N)C(O)=O)=C1OC2=CC(I)=C(C(I)=C2)O

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Nicod P, et al. Radioimmunoassay for 3,3',5'-triiodo-L-thyronine in unextracted serum: method and clinical results. J Clin Endocrinol Metab. 1976 May;42(5):823-9.  [Content Brief]

  [2]. Rebolledo RA, et al. Anti-Apoptotic Effects of 3,3',5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats. PLoS One. 2015 Oct 5;10(10):e0138749.  [Content Brief]

  [3]. Verga Falzacappa C, et al. 3,5,3'-triiodothyronine (T3) is a survival factor for pancreatic beta-cells undergoing apoptosis. J Cell Physiol. 2006 Feb;206(2):309-21.  [Content Brief]

  [4]. Bronson Kumar Khangembam, et al. Effect of cortisol and triiodothyronine bath treatments on the digestive enzyme profile and growth of atla catla larvae during ontogenic development, Aquaculture Research.13054, 48, 5, (2173-2185), (2016).