2. GPCR/G Protein Apoptosis Cell Cycle/DNA Damage
  3. Neuropeptide FF Receptor Apoptosis MDM-2/p53 PERK
  4. RFRP-3 (mouse)

RFRP-3 (mouse)  (Synonyms: Neuropeptide NPVF (mouse))

Cat. No.: HY-P10780
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RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR). RFRP-3 (mouse) induces Apoptosis (increase of p53). RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development.

For research use only. We do not sell to patients.

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RFRP-3 (mouse) Chemical Structure

RFRP-3 (mouse) Chemical Structure

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RFRP-3 (mouse) Related Antibodies

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Description

RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR). RFRP-3 (mouse) induces Apoptosis (increase of p53). RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development[1].

In Vitro

RFRP-3 (mouse) (10-1000 ng/mL, 24 h) significantly reduces Progesterone secretion but not Estradiol secretion in the ovarian granulosa cells of mice[1].
RFRP-3 (mouse) (10-1000 ng/mL, 24 h) inhibits steroidogenesis and FSHR (inhibition of p450scc, 3β-HSD, StAR, and FSHR) in the ovarian granulosa cells of mice[1].
RFRP-3 (mouse) (10-1000 ng/mL, 24 h) induces apoptosis, with lowering Bcl-2 protein expression and increasing p53 protein expression at the medium dose[1].
RFRP-3 (mouse) (10-1000 ng/mL, 24 h) suppresses ERK signaling pathway (p-ERK1/2 protein) in the ovarian granulosa cells of mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RFRP-3 (mouse) Related Antibodies

Real Time qPCR[1]

Cell Line: Granulosa cells
Concentration: 10, 100, 1000 ng/mL
Incubation Time: 24 h
Result: Reduced p450scc mRNA expression at 100 ng/mL, but did not significantly alter p450scc expression at low dose (10 ng/mL) and high dose (1000 ng/mL).
Reduced 3β-HSD, FSHR and StAR expression at 100 ng/mL and 1000 ng/mL, whereas had no significant effect at 10 ng/mL.
Molecular Weight

2073.34

Formula

C91H141N29O25S
Sequence

Val-Asn-Met-Glu-Ala-Gly-Thr-Arg-Ser-His-Phe-Pro-Ser-Leu-Pro-Gln-Arg-Phe-NH2
Sequence Shortening

VNMEAGTRSHFPSLPQRF-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RFRP-3 (mouse) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RFRP-3 (mouse)Neuropeptide NPVF (mouse)Neuropeptide FF ReceptorApoptosisMDM-2/p53PERKProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseGranulosa cellsFollicleICRGnIHProgesteroneOvarian.Inhibitorinhibitorinhibit

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