2. Signaling Pathways
  3. GPCR/G Protein
  4. Neuropeptide FF Receptor

Neuropeptide FF Receptor

 

Neuropeptide FF Receptor Isoform Specific Products:

Neuropeptide FF Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1248
    Neuropeptide FF
    		98.80%
    Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, interacts with two distinct G-protein-coupled receptors, NPFF(1) and NPFF(2) and has wide variety of physiological functions in the brain including central cardiovascular and neuroendocrine regulation.
    Neuropeptide FF
  • HY-P10395
    DP50
    		Antagonist
    DP50 is a bifunctional compound that contains an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. DP50 can be used in analgesia-related research.
    DP50
  • HY-P10377
    GUB03385
    		Agonist
    GUB03385 is a long-acting PrRP31 analogue. GUB03385 is a potent dual agonist for GPR10 (full agonist, EC50: 0.4 nM) and NPFF2R (partial agonist, EC50: 20 nM). GUB03385 has anti-obesity effect.
    GUB03385
  • HY-P10379
    palm-PrRP31
    		Agonist
    palm-PrRP31 is a potent dual receptor agonist for both GPR10 (EC50=72 pM) and NPFF-R2. palm-PrRP31 activates downstream signaling pathways through binding to its receptors, GPR10 and NPFF-R2, which results in reduced appetite and increased energy expenditure. Utilizing palm-PrRP31 facilitates the study of the mechanism of action in the nervous system, thereby elucidating the complex biological processes that regulate appetite and energy expenditure.
    palm-PrRP31
  • HY-P3873
    Neuropeptide FF (5-8)
    Neuropeptide FF (5-8) is a Neuropeptide FF (HY-P1248)-related peptide. Neuropeptide FF (5-8) with a sequence of Q-P-Q-R-F-NH2 and a Ki value of 20.9 nM.
    Neuropeptide FF (5-8)
  • HY-P10380
    palm11-PrRP31
    		Agonist
    palm11-PrRP31 is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 is GPR10 (EC50=39 pM) and NPFF-R2 effective dual agonists. palm11-PrRP31 is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction.
    palm11-PrRP31
  • HY-P10394
    DP32
    		Antagonist
    DP32 is a bifunctional compound that contains an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. DP32 can be used in analgesia-related research.
    DP32
  • HY-161405
    NPFF1-R antagonist 1
    		Inhibitor
    NPFF1-R antagonist 1 (compound 8b), a piperidine analogue, is a potent neuropeptide FF (NPFF) receptor antagonist. NPFF1-R antagonist 1 is 15-fold selective for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively.
    NPFF1-R antagonist 1
Neuropeptide FF Receptor Isoform Comparison

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