RI-STAD-2 

RI-STAD-2 is a high-affinity interfering peptide that regulates the subunit RI of protein kinase A (PKA). RI-STAD-2 interferes with the binding of AKAPs and PKA-RI by simulating the interaction between AKAPs' α-helix domain and PKA-RI's dimerization/anchoration (D/D) domain, thereby affecting PKA activity and intracellular localization. RI-STAD-2 can be used to study the role of AKAPs interaction with PKA-RI in pathological processes such as cardiovascular disease and cancer^[1].

2401.75

C₁₀₉H₁₈₁N₂₅O₃₅

{NH2-PEG3-CH2-CO}-Leu-{(S)-2-(4-pentenyl)Ala}-Gln-Tyr-Ala-{(S)-2-(4-pentenyl)Ala}-Gln-Leu-Ala-Asp-Gln-Ile-Ile-Lys-Glu-Ala-Thr-Glu-Lys ((S)-2-(4-pentenyl)Ala-2 and (S)-2-(4-pentenyl)Ala-6 stapled together with a double bond)

{NH2-PEG3-CH2-CO}-L-{(S)-2-(4-pentenyl)Ala}-QYA-{(S)-2-(4-pentenyl)Ala}-QLADQIIKEATEK ((S)-2-(4-pentenyl)Ala-2 and (S)-2-(4-pentenyl)Ala-6 stapled together with a double bond)

O=C([C@](NC1=O)(C)CCC/C=C/CCC[C@](C(N[C@H](C(N[C@H](C(N[C@H]1C)=O)CC2=CC=C(O)C=C2)=O)CCC(N)=O)=O)(C)NC([C@@H](NC(COCCOCCOCCN)=O)CC(C)C)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CCC(O)=O)=O)[C@@H](C)O)=O)C)=O)CCC(O)=O)=O)CCCCN)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCC(N)=O)=O)CC(O)=O)=O)C)=O)CC(C)C)=O)CCC(N)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Autenrieth K, et al. Defining A‐kinase anchoring protein (AKAP) specificity for the protein kinase A subunit RI (PKA‐RI)[J]. Chembiochem, 2016, 17(8): 693-697.  [Content Brief]