Ridogrel (Synonyms: R 68070)

Name: Ridogrel
Brand: MedChemExpress
SKU: HY-A0221
Rating: 4.5 (1 reviews)

Cat. No.: HY-A0221 Purity: 99.64%: FAQs
Data Sheet SDS COA Handling Instructions

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Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel is potent antiplatelet agent. Anti-inflammatory activities.

For research use only. We do not sell to patients.

Ridogrel Chemical Structure

CAS No. : 110140-89-1

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 99	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 99	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 139	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 672	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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DP EP FP IP TXA₂/TP TXB₂

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

In Vitro

In rats, R 68 070 (1.25 mg/kg orally, -2 h) singly prolongs tail bleeding times as much as a combination of TXA2 synthetase inhibition (dazoxiben 10 mg/kg) and TXA2/prostaglandin endoperoxide receptor blockade (BM 13177 40 mg/kg). In dogs, the compound reduces coronary thrombosis induced by electrical damage (1.25 mg/kg i.v.) and prevents the evolution of occlusion/reperfusion-induced arrhythmias into ventricular fibrillation (2.5 mg/kg i.v.)^[2.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

366.33

Formula

C₁₈H₁₇F₃N₂O₃

CAS No.

110140-89-1

Appearance

Solid

Color

White to light yellow

SMILES

O=C(O)CCCCO/N=C(C1=CC=CN=C1)\C2=CC=CC(C(F)(F)F)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (272.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7298 mL	13.6489 mL	27.2978 mL
5 mM	0.5460 mL	2.7298 mL	5.4596 mL
10 mM	0.2730 mL	1.3649 mL	2.7298 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.64%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (246 KB) LCMS (257 KB)

Handling Instructions (2659 KB)

References

[1]. De Clerck F, et al. R 68 070: thromboxane A2 synthetase inhibition and thromboxane A2/prostaglandin endoperoxide receptor blockade combined in one molecule--II. Pharmacological effects in vivo and ex vivo. Thromb Haemost. 1989;61(1):43-49. [Content Brief]

[2]. Di Perri T, et al. Ridogrel, una nuova molecula antiaggregante piastrinica a doppio meccanismo d'azione. Profilo farmacologico e clinico [Ridogrel, a new platelet antiaggregant molecule with a double mechanism of action. A pharmacological and clinical profile]. Recenti Prog Med. 1991;82(10):533-540. [Content Brief]

[3]. Carty E, et al. Ridogrel, a dual thromboxane synthase inhibitor and receptor antagonist: anti-inflammatory profile in inflammatory bowel disease. Aliment Pharmacol Ther. 2000;14(6):807-817. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7298 mL	13.6489 mL	27.2978 mL	68.2445 mL
	5 mM	0.5460 mL	2.7298 mL	5.4596 mL	13.6489 mL
	10 mM	0.2730 mL	1.3649 mL	2.7298 mL	6.8244 mL
	15 mM	0.1820 mL	0.9099 mL	1.8199 mL	4.5496 mL
	20 mM	0.1365 mL	0.6824 mL	1.3649 mL	3.4122 mL
	25 mM	0.1092 mL	0.5460 mL	1.0919 mL	2.7298 mL
	30 mM	0.0910 mL	0.4550 mL	0.9099 mL	2.2748 mL
	40 mM	0.0682 mL	0.3412 mL	0.6824 mL	1.7061 mL
	50 mM	0.0546 mL	0.2730 mL	0.5460 mL	1.3649 mL
	60 mM	0.0455 mL	0.2275 mL	0.4550 mL	1.1374 mL
	80 mM	0.0341 mL	0.1706 mL	0.3412 mL	0.8531 mL
	100 mM	0.0273 mL	0.1365 mL	0.2730 mL	0.6824 mL

Ridogrel Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ridogrel110140-89-1R 68070R68070R-68070Prostaglandin Receptorantiplateletthromboxane synthaseinflammatory bowel diseaseInhibitorinhibitorinhibit

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Ridogrel (Synonyms: R 68070)

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Ridogrel Related Antibodies

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Complete Stock Solution Preparation Table

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