2. Others
  3. Isotope-Labeled Compounds
  4. Riociguat-13C,d6

Riociguat-13C,d6  (Synonyms: BAY 632521-13C,d6)

Cat. No.: HY-14779S Purity: ≥99.0%
COA Handling Instructions

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Riociguat-13C,d6 is the 13C and deuterium labeled Riociguat (HY-14779). Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

For research use only. We do not sell to patients.

Riociguat-<sup>13</sup>C,d<sub>6</sub> Chemical Structure

Riociguat-13C,d6 Chemical Structure

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1 mg USD 750 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Riociguat-13C,d6:

Riociguat-13C,d6 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Riociguat-13C,d6 is the 13C and deuterium labeled Riociguat (HY-14779). Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

IC50 & Target

sGC[2]
In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
Riocigua stimulates the recombinant sGC concentration dependently from 0.1 to 100 μM with a two-fold to 73-fold effect by an NO-independent but haem-dependent mechanism[1]. Riociguat inhibits platelet function in washed platelets but not in whole blood, and exerts no direct effects on contractility and relaxation of cardiac myocytes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Riociguat-13C,d6 Related Antibodies
In Vivo

Riociguat (10 mg/kg/d, p.o.) partially reverses the pulmonary arterial hypertension, the right heart hypertrophy and the structural remodelling of the lung vasculature in chronic treatment of hypoxic mice and MCT-injected rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

429.45

Formula

C1913CH13D6FN8O2
Unlabeled CAS

625115-55-1
Appearance

Solid

Color

White to off-white

SMILES

O=C(OC([2H])([2H])[2H])N(C1=C(N)N=C(C2=NN(CC3=CC=CC=C3F)C4=NC=CC=C42)N=C1N)[13C]([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 10 mg/mL (23.29 mM)

DMSO : ≥ 10 mg/mL (23.29 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 10 mg/mL (23.29 mM)

DMSO : ≥ 10 mg/mL (23.29 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO:PBS(pH7.2) (1:1) : ≥ 0.5 mg/mL (1.16 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3286 mL 11.6428 mL 23.2856 mL
5 mM 0.4657 mL 2.3286 mL 4.6571 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (262 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO:PBS(pH7.2) (1:1) / DMF / DMSO / DMF / DMSO 1 mM 2.3286 mL 11.6428 mL 23.2856 mL 58.2140 mL
DMF / DMSO / DMF / DMSO 5 mM 0.4657 mL 2.3286 mL 4.6571 mL 11.6428 mL
10 mM 0.2329 mL 1.1643 mL 2.3286 mL 5.8214 mL
15 mM 0.1552 mL 0.7762 mL 1.5524 mL 3.8809 mL
20 mM 0.1164 mL 0.5821 mL 1.1643 mL 2.9107 mL
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Riociguat-13C,d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Riociguat-13C,d6BAY 632521-13C,d6Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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