1. Apoptosis
  2. RIP kinase
  3. RIPK1-IN-17

RIPK1/3-IN-17 (Compound 10) is a RIPK1 and RIPK3 inhibitor. RIPK1/3-IN-17 specifically inhibits necroptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation.

For research use only. We do not sell to patients.

RIPK1-IN-17 Chemical Structure

RIPK1-IN-17 Chemical Structure

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5 mg In-stock
10 mg   Get quote  
50 mg   Get quote  

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Description

RIPK1/3-IN-17 (Compound 10) is a RIPK1 and RIPK3 inhibitor. RIPK1/3-IN-17 specifically inhibits necroptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation[1].

Molecular Weight

529.51

Formula

C26H19F4N3O3S

Appearance

Solid

Color

White to off-white

SMILES

O=C(CC1=CC=CC(OC(F)(F)F)=C1)NC2=C(C=CC(C3=CC=C4N=C(SC4=C3)NC(C5CC5)=O)=C2)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (94.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8885 mL 9.4427 mL 18.8854 mL
5 mM 0.3777 mL 1.8885 mL 3.7771 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8885 mL 9.4427 mL 18.8854 mL 47.2135 mL
5 mM 0.3777 mL 1.8885 mL 3.7771 mL 9.4427 mL
10 mM 0.1889 mL 0.9443 mL 1.8885 mL 4.7213 mL
15 mM 0.1259 mL 0.6295 mL 1.2590 mL 3.1476 mL
20 mM 0.0944 mL 0.4721 mL 0.9443 mL 2.3607 mL
25 mM 0.0755 mL 0.3777 mL 0.7554 mL 1.8885 mL
30 mM 0.0630 mL 0.3148 mL 0.6295 mL 1.5738 mL
40 mM 0.0472 mL 0.2361 mL 0.4721 mL 1.1803 mL
50 mM 0.0378 mL 0.1889 mL 0.3777 mL 0.9443 mL
60 mM 0.0315 mL 0.1574 mL 0.3148 mL 0.7869 mL
80 mM 0.0236 mL 0.1180 mL 0.2361 mL 0.5902 mL
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RIPK1-IN-17 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
RIPK1-IN-17
Cat. No.:
HY-157039
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