RIPK1-IN-17

Cat. No.: HY-157039 Purity: 98.38%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

RIPK1/3-IN-17 (Compound 10) is a RIPK1 and RIPK3 inhibitor. RIPK1/3-IN-17 specifically inhibits necroptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation.

For research use only. We do not sell to patients.

RIPK1-IN-17 Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Biological Activity
Purity & Documentation
References
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Description

RIPK1/3-IN-17 (Compound 10) is a RIPK1 and RIPK3 inhibitor. RIPK1/3-IN-17 specifically inhibits necroptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation^[1].

Molecular Weight

529.51

Formula

C₂₆H₁₉F₄N₃O₃S

Appearance

Solid

Color

White to off-white

SMILES

O=C(CC1=CC=CC(OC(F)(F)F)=C1)NC2=C(C=CC(C3=CC=C4N=C(SC4=C3)NC(C5CC5)=O)=C2)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (94.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8885 mL	9.4427 mL	18.8854 mL
5 mM	0.3777 mL	1.8885 mL	3.7771 mL
10 mM	0.1889 mL	0.9443 mL	1.8885 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.38%

Select Batch:

Data Sheet (265 KB) SDS (251 KB)

COA (244 KB) HNMR (300 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Fang JJ, et al. Insight from Linker Investigations: Discovery of a Novel Phenylbenzothiazole Necroptosis Inhibitor Targeting Receptor-Interacting Protein Kinase 1 (RIPK1) from a Phenoxybenzothiazole Compound with Dual RIPK1/3 Targeting Activity. J Med Chem. 2023 Nov 2. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8885 mL	9.4427 mL	18.8854 mL	47.2135 mL
	5 mM	0.3777 mL	1.8885 mL	3.7771 mL	9.4427 mL
	10 mM	0.1889 mL	0.9443 mL	1.8885 mL	4.7213 mL
	15 mM	0.1259 mL	0.6295 mL	1.2590 mL	3.1476 mL
	20 mM	0.0944 mL	0.4721 mL	0.9443 mL	2.3607 mL
	25 mM	0.0755 mL	0.3777 mL	0.7554 mL	1.8885 mL
	30 mM	0.0630 mL	0.3148 mL	0.6295 mL	1.5738 mL
	40 mM	0.0472 mL	0.2361 mL	0.4721 mL	1.1803 mL
	50 mM	0.0378 mL	0.1889 mL	0.3777 mL	0.9443 mL
	60 mM	0.0315 mL	0.1574 mL	0.3148 mL	0.7869 mL
	80 mM	0.0236 mL	0.1180 mL	0.2361 mL	0.5902 mL

RIPK1-IN-17 Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RIPK1-IN-17RIP kinaseReceptor-interacting protein kinasesRIPKRIPK1 inhibitorRIPK3 inhibitorInhibitorinhibitorinhibit

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