Rivaroxaban-d₄ (Synonyms: BAY 59-7939-d₄)

Cat. No.: HY-50903S Purity: 98.91%: FAQs
Data Sheet SDS COA Handling Instructions

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Rivaroxaban-d₄ is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent，selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM)[1][2].

For research use only. We do not sell to patients.

Rivaroxaban-d<sub>4</sub> Chemical Structure

Rivaroxaban-d₄ Chemical Structure

CAS No. : 1132681-38-9

Size	Price	Stock	Quantity
1 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 690	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Rivaroxaban-d₄:

Rivaroxaban In-stock

1 Publications Citing Use of MCE Rivaroxaban-d₄

•Molecules. 2023 Feb 28.

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Description

IC₅₀ & Target

IC50: 0.7 nM (Factor Xa); Ki: 0.4 nM (Factor Xa)^[1]^[2]

Molecular Weight

439.91

Formula

C₁₉H₁₄D₄ClN₃O₅S

CAS No.

1132681-38-9

Unlabeled CAS

366789-02-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(Cl)S1)NC[C@H]2CN(C3=C([2H])C([2H])=C(N4C(COCC4)=O)C([2H])=C3[2H])C(O2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (113.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2732 mL	11.3660 mL	22.7319 mL
5 mM	0.4546 mL	2.2732 mL	4.5464 mL
10 mM	0.2273 mL	1.1366 mL	2.2732 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.91%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (249 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Roehrig S, et al. Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor. J Med Chem. 2005 Sep 22;48(19) [Content Brief]

[2]. Perzborn E, et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939--an oral, direct Factor Xa inhibitor. J Thromb Haemost. 2005 Mar;3(3):514-21. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	2.2732 mL	11.3660 mL	22.7319 mL	56.8298 mL
	5 mM	0.4546 mL	2.2732 mL	4.5464 mL	11.3660 mL
	10 mM	0.2273 mL	1.1366 mL	2.2732 mL	5.6830 mL
	15 mM	0.1515 mL	0.7577 mL	1.5155 mL	3.7887 mL
	20 mM	0.1137 mL	0.5683 mL	1.1366 mL	2.8415 mL
	25 mM	0.0909 mL	0.4546 mL	0.9093 mL	2.2732 mL
	30 mM	0.0758 mL	0.3789 mL	0.7577 mL	1.8943 mL
	40 mM	0.0568 mL	0.2841 mL	0.5683 mL	1.4207 mL
	50 mM	0.0455 mL	0.2273 mL	0.4546 mL	1.1366 mL
	60 mM	0.0379 mL	0.1894 mL	0.3789 mL	0.9472 mL
	80 mM	0.0284 mL	0.1421 mL	0.2841 mL	0.7104 mL
	100 mM	0.0227 mL	0.1137 mL	0.2273 mL	0.5683 mL

Rivaroxaban-d₄ Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rivaroxaban-d₄1132681-38-9BAY 59-7939-d₄Factor XaFxaDeuteriumlabeledanti-FXapotencyInhibitorinhibitorinhibit

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Rivaroxaban-d4 (Synonyms: BAY 59-7939-d4)

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Other Forms of Rivaroxaban-d4:

Rivaroxaban-d4 Related Antibodies

1 Publications Citing Use of MCE Rivaroxaban-d4

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Complete Stock Solution Preparation Table

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Rivaroxaban-d₄ (Synonyms: BAY 59-7939-d₄)

Other Forms of Rivaroxaban-d₄:

Rivaroxaban-d₄ Related Antibodies

1 Publications Citing Use of MCE Rivaroxaban-d₄

Rivaroxaban-d₄ Related Classifications