1. Metabolic Enzyme/Protease Anti-infection Stem Cell/Wnt MAPK/ERK Pathway Autophagy
  2. Phosphatase Phospholipase HIV Protease ERK Autophagy
  3. RK-682

RK-682 is the inhibitor for protein tyrosine phosphatase (PTPase), heparanase, phospholipase A2 and HIV-1 protease. RK-682 inhibits the dephosphorylation of CD45 (IC50 is 54 μM) and VHR (IC50 is 2.0 μM), and thereby inhibits the ERK signaling pathway. RK-682 inhibits the cell viability of cancer cell MGH-U3, T24 and UROtsa with IC50s of 78.2, 43.2 and 145 nM, respectively, arrests the cell cycle at G1/S phase, inhibits the cell migration and autophagy in MGH-U3 and T24.

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RK-682 Chemical Structure

RK-682 Chemical Structure

CAS No. : 150627-37-5

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Description

RK-682 is the inhibitor for protein tyrosine phosphatase (PTPase), heparanase, phospholipase A2 and HIV-1 protease. RK-682 inhibits the dephosphorylation of CD45 (IC50 is 54 μM) and VHR (IC50 is 2.0 μM), and thereby inhibits the ERK signaling pathway. RK-682 inhibits the cell viability of cancer cell MGH-U3, T24 and UROtsa with IC50s of 78.2, 43.2 and 145 nM, respectively, arrests the cell cycle at G1/S phase, inhibits the cell migration and autophagy in MGH-U3 and T24[1][2][3].

Molecular Weight

368.51

Formula

C21H36O5

CAS No.
SMILES

CCCCCCCCCCCCCCCC(C1=C([C@@H](CO)OC1=O)O)=O

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RK-682
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HY-135564A
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