(R)-Indeloxazine benzenesulfonate  (Synonyms: AS1069562; (R)-YM-08054 benzenesulfonate)

(R)-Indeloxazine benzenesulfonate (AS1069562) is an orally active 5-HT and NE reuptake inhibitor, with IC₅₀ values of 0.35 μM and 3.3 μM, respectively. (R)-Indeloxazine benzenesulfonate (AS1069562) possesses curative-like analgesic effect. (R)-Indeloxazine benzenesulfonate (AS1069562) might improve nerve function impairment via the amelioration of neurotrophic support^[1][2].

(R)-Indeloxazine benzenesulfonate (AS1069562, STZ-induced diabetic rats, orally, 3, 10, and 30 mg/kg) has a longer-lasting analgesic effect administered for 4 weeks in a rat model of Streptozotocin (STZ, HY-13753)-induced diabetic neuropathic pain^[2].
(R)-Indeloxazine benzenesulfonate (AS1069562, STZ-induced diabetic rats, orally, 3, 10, and 30 mg/kg) significantly restores decreased insulin-like growth factor 1 and fibroblast growth factor 2 mRNA levels in dorsal root ganglion and spinal cord, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

389.47

C₂₀H₂₃NO₅S

1623762-83-3

O=S(O)(C1=CC=CC=C1)=O.[C@@H]2(CNCCO2)COC3=C4C(C=CC4)=CC=C3

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• [1]. Nobuhito Murai, et al. AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover. J Pharmacol Exp Ther. 2014 Mar;348(3):372-82.  [Content Brief]