2. PI3K/Akt/mTOR
  3. mTOR
  4. RMC-4627

RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.

For research use only. We do not sell to patients.

RMC-4627 Chemical Structure

RMC-4627 Chemical Structure

CAS No. : 2250059-52-8

Size Price Stock Quantity
1 mg USD 1080 In-stock
5 mg USD 2144 In-stock
10 mg USD 3413 In-stock
25 mg USD 6843 In-stock
50 mg USD 10938 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

RMC-4627 Related Antibodies

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mTOR mTORC1 mTORC2

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Description

RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.

Molecular Weight

1781.17

Formula

C93H141N11O23
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

NC1=C2C(C3=CC4=CC(O)=CC=C4N3)=NN(C2=NC=N1)CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCN5C=C(N=N5)CCCCO[C@H]6[C@@H](C[C@@H](CC6)C[C@H]([C@@]7([H])OC([C@@]8([H])N(CCCC8)C(C([C@@]9(O[C@](CC[C@H]9C)([H])C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@H](C([C@@H]([C@@H](/C(C)=C/[C@H](C(C7)=O)C)O)OC)=O)C)C)OC)O)=O)=O)=O)C)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (56.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5614 mL 2.8071 mL 5.6143 mL
5 mM 0.1123 mL 0.5614 mL 1.1229 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5614 mL 2.8071 mL 5.6143 mL 14.0357 mL
5 mM 0.1123 mL 0.5614 mL 1.1229 mL 2.8071 mL
10 mM 0.0561 mL 0.2807 mL 0.5614 mL 1.4036 mL
15 mM 0.0374 mL 0.1871 mL 0.3743 mL 0.9357 mL
20 mM 0.0281 mL 0.1404 mL 0.2807 mL 0.7018 mL
25 mM 0.0225 mL 0.1123 mL 0.2246 mL 0.5614 mL
30 mM 0.0187 mL 0.0936 mL 0.1871 mL 0.4679 mL
40 mM 0.0140 mL 0.0702 mL 0.1404 mL 0.3509 mL
50 mM 0.0112 mL 0.0561 mL 0.1123 mL 0.2807 mL
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RMC-4627 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RMC-46272250059-52-8RMC4627RMC 4627mTORMammalian target of RapamycinInhibitorinhibitorinhibit

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