2. Metabolic Enzyme/Protease
  3. Lipoxygenase
  4. Ro 3-1314

Ro 3-1314  (Synonyms: 9a,12a-Octadecadiynoic acid)

Cat. No.: HY-N8276
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Ro 3-1314 (9a,12a-Octadecadiynoic acid) is a plant lipoxygenase inhibitor. Ro 3-1314 is a linoleic acid metabolism inhibitor. Ro 3-1314 stimulates the antigen-induced contraction of guinea-pig tracheal spirals and the immunological release of slow reacting substance of anaphylaxis (SRS-A) from actively sensitized guinea-pig lung fragments.

For research use only. We do not sell to patients.

Ro 3-1314 Chemical Structure

Ro 3-1314 Chemical Structure

CAS No. : 2012-14-8

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Based on 1 publication(s) in Google Scholar

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Description

Ro 3-1314 (9a,12a-Octadecadiynoic acid) is a plant lipoxygenase inhibitor. Ro 3-1314 is a linoleic acid metabolism inhibitor. Ro 3-1314 stimulates the antigen-induced contraction of guinea-pig tracheal spirals and the immunological release of slow reacting substance of anaphylaxis (SRS-A) from actively sensitized guinea-pig lung fragments[1].

Molecular Weight

276.41

Formula

C18H28O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCCCCCCC#CCC#CCCCCC)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (361.78 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6178 mL 18.0891 mL 36.1781 mL
5 mM 0.7236 mL 3.6178 mL 7.2356 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (239 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6178 mL 18.0891 mL 36.1781 mL 90.4454 mL
5 mM 0.7236 mL 3.6178 mL 7.2356 mL 18.0891 mL
10 mM 0.3618 mL 1.8089 mL 3.6178 mL 9.0445 mL
15 mM 0.2412 mL 1.2059 mL 2.4119 mL 6.0297 mL
20 mM 0.1809 mL 0.9045 mL 1.8089 mL 4.5223 mL
25 mM 0.1447 mL 0.7236 mL 1.4471 mL 3.6178 mL
30 mM 0.1206 mL 0.6030 mL 1.2059 mL 3.0148 mL
40 mM 0.0904 mL 0.4522 mL 0.9045 mL 2.2611 mL
50 mM 0.0724 mL 0.3618 mL 0.7236 mL 1.8089 mL
60 mM 0.0603 mL 0.3015 mL 0.6030 mL 1.5074 mL
80 mM 0.0452 mL 0.2261 mL 0.4522 mL 1.1306 mL
100 mM 0.0362 mL 0.1809 mL 0.3618 mL 0.9045 mL
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Ro 3-1314 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 3-13142012-14-89a,12a-Octadecadiynoic acidLipoxygenaseLOXlinoleic acid metabolism,LipoxygenaseInhibitorinhibitorinhibit

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