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  4. RO3244794

RO3244794 is a potent and selective IP (prostacyclin) receptor antagonist, with a pKi of 7.7 and 6.9 in human platelet and recombinant IP receptor system, respectively. RO3244794 exhibits analgesic and anti-inflammatory potential.

For research use only. We do not sell to patients.

RO3244794 Chemical Structure

RO3244794 Chemical Structure

CAS No. : 361457-01-4

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1 mg USD 350 In-stock
5 mg USD 860 In-stock
10 mg USD 1080 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

RO3244794 is a potent and selective IP (prostacyclin) receptor antagonist, with a pKi of 7.7 and 6.9 in human platelet and recombinant IP receptor system, respectively. RO3244794 exhibits analgesic and anti-inflammatory potential[1].

Molecular Weight

451.42

Formula

C25H19F2NO5
CAS No.
SMILES

FC(C=C1)=CC=C1C[C@H](C(O)=O)NC(OCC2=CC3=CC(C4=CC=C(C=C4)F)=CC=C3O2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (110.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2152 mL 11.0762 mL 22.1523 mL
5 mM 0.4430 mL 2.2152 mL 4.4305 mL
View the Complete Stock Solution Preparation Table

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Purity & Documentation
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2152 mL 11.0762 mL 22.1523 mL 55.3808 mL
5 mM 0.4430 mL 2.2152 mL 4.4305 mL 11.0762 mL
10 mM 0.2215 mL 1.1076 mL 2.2152 mL 5.5381 mL
15 mM 0.1477 mL 0.7384 mL 1.4768 mL 3.6921 mL
20 mM 0.1108 mL 0.5538 mL 1.1076 mL 2.7690 mL
25 mM 0.0886 mL 0.4430 mL 0.8861 mL 2.2152 mL
30 mM 0.0738 mL 0.3692 mL 0.7384 mL 1.8460 mL
40 mM 0.0554 mL 0.2769 mL 0.5538 mL 1.3845 mL
50 mM 0.0443 mL 0.2215 mL 0.4430 mL 1.1076 mL
60 mM 0.0369 mL 0.1846 mL 0.3692 mL 0.9230 mL
80 mM 0.0277 mL 0.1385 mL 0.2769 mL 0.6923 mL
100 mM 0.0222 mL 0.1108 mL 0.2215 mL 0.5538 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RO3244794361457-01-4RO 3244794RO-3244794OthersInhibitorinhibitorinhibit

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