2. Metabolic Enzyme/Protease
  3. FABP
  4. RO6806051

RO6806051 (compound12) is a potent dual fatty acid binding protein 4 and 5 (FABP4 and FABP5) inhibitor with good selectivity and absorption, distribution, metabolism and excretion (eADME) properties.

For research use only. We do not sell to patients.

RO6806051 Chemical Structure

RO6806051 Chemical Structure

CAS No. : 1433901-75-7

Size Price Stock Quantity
5 mg USD 218 In-stock
10 mg USD 350 In-stock
25 mg USD 700 In-stock
50 mg USD 980 In-stock
100 mg USD 1370 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

RO6806051 (compound12) is a potent dual fatty acid binding protein 4 and 5 (FABP4 and FABP5) inhibitor with good selectivity and absorption, distribution, metabolism and excretion (eADME) properties[1].

Molecular Weight

390.87

Formula

C21H19ClN6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CC2=C(N=C(N3CCCCC3)C(C4=NN=NN4)=C2C5=CC=CC=C5)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (319.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5584 mL 12.7920 mL 25.5840 mL
5 mM 0.5117 mL 2.5584 mL 5.1168 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5584 mL 12.7920 mL 25.5840 mL 63.9599 mL
5 mM 0.5117 mL 2.5584 mL 5.1168 mL 12.7920 mL
10 mM 0.2558 mL 1.2792 mL 2.5584 mL 6.3960 mL
15 mM 0.1706 mL 0.8528 mL 1.7056 mL 4.2640 mL
20 mM 0.1279 mL 0.6396 mL 1.2792 mL 3.1980 mL
25 mM 0.1023 mL 0.5117 mL 1.0234 mL 2.5584 mL
30 mM 0.0853 mL 0.4264 mL 0.8528 mL 2.1320 mL
40 mM 0.0640 mL 0.3198 mL 0.6396 mL 1.5990 mL
50 mM 0.0512 mL 0.2558 mL 0.5117 mL 1.2792 mL
60 mM 0.0426 mL 0.2132 mL 0.4264 mL 1.0660 mL
80 mM 0.0320 mL 0.1599 mL 0.3198 mL 0.7995 mL
100 mM 0.0256 mL 0.1279 mL 0.2558 mL 0.6396 mL
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RO6806051 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RO68060511433901-75-7RO 6806051RO-6806051FABPFatty acid-binding proteinInhibitorinhibitorinhibit

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