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Rocbrutinib is a Bruton's tyrosine kinase inhibitor with antineoplastic effect.

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Rocbrutinib Chemical Structure

Rocbrutinib Chemical Structure

CAS No. : 2485861-07-0

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Rocbrutinib Related Antibodies

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Description

Rocbrutinib is a Bruton's tyrosine kinase inhibitor with antineoplastic effect[1].

Molecular Weight

761.91

Formula

C42H51N9O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC(CC(C)(C3)C)=C3N2CCN1C4=C(C(C(N=C5NC6=CC(NC(C=C)=O)=C(N7[C@H](CN(C8CCOCC8)CC7)C)C=C6)=CN(C)C5=O)=CC=N4)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (164.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3125 mL 6.5625 mL 13.1249 mL
5 mM 0.2625 mL 1.3125 mL 2.6250 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3125 mL 6.5625 mL 13.1249 mL 32.8123 mL
5 mM 0.2625 mL 1.3125 mL 2.6250 mL 6.5625 mL
10 mM 0.1312 mL 0.6562 mL 1.3125 mL 3.2812 mL
15 mM 0.0875 mL 0.4375 mL 0.8750 mL 2.1875 mL
20 mM 0.0656 mL 0.3281 mL 0.6562 mL 1.6406 mL
25 mM 0.0525 mL 0.2625 mL 0.5250 mL 1.3125 mL
30 mM 0.0437 mL 0.2187 mL 0.4375 mL 1.0937 mL
40 mM 0.0328 mL 0.1641 mL 0.3281 mL 0.8203 mL
50 mM 0.0262 mL 0.1312 mL 0.2625 mL 0.6562 mL
60 mM 0.0219 mL 0.1094 mL 0.2187 mL 0.5469 mL
80 mM 0.0164 mL 0.0820 mL 0.1641 mL 0.4102 mL
100 mM 0.0131 mL 0.0656 mL 0.1312 mL 0.3281 mL
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Rocbrutinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rocbrutinib2485861-07-0LP-168LP168LP 168OthersInhibitorinhibitorinhibit

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