2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton Metabolic Enzyme/Protease JAK/STAT Signaling
  3. ROCK MMP STAT
  4. ROCK2-IN-7

ROCK2-IN-7 is a kinase inhibitor targeting to ROCK2. ROCK2-IN-7 inhibits ROCK2/pSTAT3 Signaling. ROCK2-IN-7 suppresses systemic immunity activation and attenuates inflammation in psoriasis model.

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ROCK2-IN-7 Chemical Structure

ROCK2-IN-7 Chemical Structure

CAS No. : 3000541-95-4

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ROCK2-IN-7 Related Antibodies

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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STAT3 STAT5 STAT6 STAT1

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Description

ROCK2-IN-7 is a kinase inhibitor targeting to ROCK2. ROCK2-IN-7 inhibits ROCK2/pSTAT3 Signaling. ROCK2-IN-7 suppresses systemic immunity activation and attenuates inflammation in psoriasis model[1].

IC50 & Target

ROCK2

 

MMP-2

 

Stat-3

 

In Vitro

ROCK2-IN-7 (2-5 μM, 24h) inhibits ROCK2/pSTAT3 Signaling in HaCaT cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ROCK2-IN-7 Related Antibodies

Western Blot Analysis

Cell Line: HaCaT cells
Concentration: 2 μM, 5 μM
Incubation Time: 24 h
Result: Inhibited the expression of matrix metalloproteinase-2 (MMP2), Fibronectin (FN), N-cadherin, Elastin involved in psoriasis pathogenesis.
Decreased phosphorylation of STAT3.
In Vivo

ROCK2-IN-7 (20-80 mg/kg, Oral gavage (p.o.), for seven consecutive days) reduces key interleukins associated with the IL-23/Th17 axis and important factors involved in keratinocyte proliferation in IMQ-induced skin inflammation model [1].
ROCK2-IN-7 (20-80 mg/kg, Oral gavage (p.o.), for seven consecutive days) inhibits the thickening of the epidermis and suppresses systemic immunity activation and attenuate inflammation in imiquimod (IMQ)-induced skin inflammation model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: IMQ-induced skin inflammation
Dosage: 20 mg/kg , 40 mg/kg, 80 mg/kg
Administration: Oral gavage (p.o.)
Result: Decrease the mRNA levels of interleukin (IL)-17A, IL-17F, IL-22, and IL-23.
Decreased phosphorylation of STAT3.
Attenuated psoriasis-like symptoms including invasive erythema, roughness, swelling, and scales.
Reduced the spleen index.
Reduced the number of IL-17A+ cells.
Reduced the number of cells positive for phosphorylated signal transducers and activators of transcription 3 (pSTAT3) and transcription 5 (pSTAT5).
Reversed the thickening of the epidermis.
Decreased the number of Ki67+ cells.
Molecular Weight

445.53

Formula

C26H28FN5O
CAS No.
SMILES

O=C1N(C=C(C(C)=C1)F)C2=CC(CN[C@H]3CCC[C@@H](C3)NC4=CC=C5NN=CC5=C4)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ROCK2-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ROCK2-IN-73000541-95-4ROCKMMPSTATRho-associated protein kinaseRho-associated kinaseRho-kinaseROKMatrix metalloproteinasesPsoriasisROCK2 inhibitorHaCaT cellsPsoriasis-like mouse modelInhibitorinhibitorinhibit

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