RP-001 hydrochloride

Name: RP-001 hydrochloride
Brand: MedChemExpress
SKU: HY-101939A
Rating: 4.5 (1 reviews)

Cat. No.: HY-101939A Purity: 98.8%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

RP-001 hydrochloride is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC₅₀ of 9 pM. RP-00 hydrochloride induces internalization and polyubiquitination of S1P1. RP-001 hydrochloride has little activity on S1P2-S1P4 and only moderate affinity for S1P5.

For research use only. We do not sell to patients.

RP-001 hydrochloride Chemical Structure

CAS No. : 1781880-34-9

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of RP-001 hydrochloride:

RP-001 Get quote

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

RP-001 hydrochloride elicits dose-dependent lymphopenia of CD4⁺ T cells. RP-001 hydrochloride induces acute lymphopenia with rapid recovery to untreated levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

RP-001 hydrochloride causes dose-dependent rapid lymphopenia with an EC₅₀ of 0.03 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

468.93

Formula

C₂₄H₂₅ClN₄O₄

CAS No.

1781880-34-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCNC1CCC2=C1C=CC=C2C3=NOC(C4=CC=C(OC(C)C)C(C#N)=C4)=N3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 29.4 mg/mL (62.70 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1325 mL	10.6626 mL	21.3251 mL
5 mM	0.4265 mL	2.1325 mL	4.2650 mL
10 mM	0.2133 mL	1.0663 mL	2.1325 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.8%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (254 KB) Elemental Analysis Report (112 KB)

Handling Instructions (2659 KB)

References

[1]. Cahalan SM, et al. Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice. Nat Chem Biol. 2011 May;7(5):254-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1325 mL	10.6626 mL	21.3251 mL	53.3129 mL
	5 mM	0.4265 mL	2.1325 mL	4.2650 mL	10.6626 mL
	10 mM	0.2133 mL	1.0663 mL	2.1325 mL	5.3313 mL
	15 mM	0.1422 mL	0.7108 mL	1.4217 mL	3.5542 mL
	20 mM	0.1066 mL	0.5331 mL	1.0663 mL	2.6656 mL
	25 mM	0.0853 mL	0.4265 mL	0.8530 mL	2.1325 mL
	30 mM	0.0711 mL	0.3554 mL	0.7108 mL	1.7771 mL
	40 mM	0.0533 mL	0.2666 mL	0.5331 mL	1.3328 mL
	50 mM	0.0427 mL	0.2133 mL	0.4265 mL	1.0663 mL
	60 mM	0.0355 mL	0.1777 mL	0.3554 mL	0.8885 mL