2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. RP 48497

RP 48497, an impurity of Eszopiclone, is a photodegradation product of Eszopiclone. Eszopiclone is a non-benzodiazepine agent used in the treatment of insomnia.

For research use only. We do not sell to patients.

RP 48497 Chemical Structure

RP 48497 Chemical Structure

CAS No. : 148891-53-6

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RP 48497 Related Antibodies

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Description

RP 48497, an impurity of Eszopiclone, is a photodegradation product of Eszopiclone. Eszopiclone is a non-benzodiazepine agent used in the treatment of insomnia[1].

In Vitro

RP 48497 is a non-chiral potential photodegradation product whose formation is caused by bright light[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RP 48497 Related Antibodies
Molecular Weight

246.65

Formula

C11H7ClN4O
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C1N(C2=NC=C(Cl)C=C2)CC3=NC=CN=C31
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (33.77 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0543 mL 20.2716 mL 40.5433 mL
5 mM 0.8109 mL 4.0543 mL 8.1087 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.79%

COA (247 KB) HNMR (248 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0543 mL 20.2716 mL 40.5433 mL 101.3582 mL
5 mM 0.8109 mL 4.0543 mL 8.1087 mL 20.2716 mL
10 mM 0.4054 mL 2.0272 mL 4.0543 mL 10.1358 mL
15 mM 0.2703 mL 1.3514 mL 2.7029 mL 6.7572 mL
20 mM 0.2027 mL 1.0136 mL 2.0272 mL 5.0679 mL
25 mM 0.1622 mL 0.8109 mL 1.6217 mL 4.0543 mL
30 mM 0.1351 mL 0.6757 mL 1.3514 mL 3.3786 mL
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RP 48497 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RP 48497148891-53-6RP48497RP-48497Drug MetaboliteimpurityphotodegradationproductinsomniaInhibitorinhibitorinhibit

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