Rp-8-Br-cGMPS sodium  (Synonyms: Rp-8-bromo-Cyclic GMPS sodium)

Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca²⁺-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca²⁺ reduction by activating Ca²⁺-ATPase and subsequently removing Ca²⁺ from the cell^[1][2].

462.15

C₁₀H₁₀BrN₅NaO₆PS

208445-06-1

O=C1C2=C(N([C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@]4(S[Na])=O)O3)C(Br)=N2)NC(N)=N1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Rashatwar SS, et, al. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5685-9.  [Content Brief]

  [2]. Barnstable CJ, et al. Modulation of synaptic function by cGMP and cGMP-gated cation channels. Neurochem Int. 2004 Nov;45(6):875-84.  [Content Brief]