Rp-8-Br-cGMPS  (Synonyms: Rp-8-bromo-Cyclic GMPS)

Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca²⁺-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca²⁺ reduction by activating Ca²⁺-ATPase and subsequently removing Ca²⁺ from the cell^[1][2].

440.17

C₁₀H₁₁BrN₅O₆PS

150418-07-8

O=C1C2=C(N([C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@]4(S)=O)O3)C(Br)=N2)NC(N)=N1

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• [1]. Rashatwar SS, et, al. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5685-9.  [Content Brief]

  [2]. Barnstable CJ, et al. Modulation of synaptic function by cGMP and cGMP-gated cation channels. Neurochem Int. 2004 Nov;45(6):875-84.  [Content Brief]