2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. RS 39604

RS 39604 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. RS 39604 displays a low affinity (pKi<6.5) for 5-HT1A, 5-HT2C, 5-HT3, α1c, D1, D2, M1, M2, AT1, B1 and opioid mu receptors and moderate affinity for δ1, (pKi=6.8) and δ2 (pKi=7.8) sites.

For research use only. We do not sell to patients.

RS 39604 Chemical Structure

RS 39604 Chemical Structure

CAS No. : 167710-87-4

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5 mg USD 490 Ask For Quote & Lead Time
10 mg USD 790 Ask For Quote & Lead Time

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RS 39604 Related Antibodies

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Description

RS 39604 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. RS 39604 displays a low affinity (pKi<6.5) for 5-HT1A, 5-HT2C, 5-HT3, α1c, D1, D2, M1, M2, AT1, B1 and opioid mu receptors and moderate affinity for δ1, (pKi=6.8) and δ2 (pKi=7.8) sites[1].

IC50 & Target[1]

5-HT4 Receptor

9.1 (pKi)

Molecular Weight

590.56

Formula

C26H37Cl2N3O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(NCCN1CCC(CCC(C2=CC(Cl)=C(N)C=C2OCC3=CC(OC)=CC(OC)=C3)=O)CC1)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (84.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6933 mL 8.4665 mL 16.9331 mL
5 mM 0.3387 mL 1.6933 mL 3.3866 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6933 mL 8.4665 mL 16.9331 mL 42.3327 mL
5 mM 0.3387 mL 1.6933 mL 3.3866 mL 8.4665 mL
10 mM 0.1693 mL 0.8467 mL 1.6933 mL 4.2333 mL
15 mM 0.1129 mL 0.5644 mL 1.1289 mL 2.8222 mL
20 mM 0.0847 mL 0.4233 mL 0.8467 mL 2.1166 mL
25 mM 0.0677 mL 0.3387 mL 0.6773 mL 1.6933 mL
30 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.4111 mL
40 mM 0.0423 mL 0.2117 mL 0.4233 mL 1.0583 mL
50 mM 0.0339 mL 0.1693 mL 0.3387 mL 0.8467 mL
60 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.7055 mL
80 mM 0.0212 mL 0.1058 mL 0.2117 mL 0.5292 mL
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RS 39604 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RS 39604167710-87-4RS39604RS-396045-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorselectiveorally activelong-lastingvisceral paincolorectal distensionInhibitorinhibitorinhibit

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