RS 39604

Cat. No.: HY-101343 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

RS 39604 is a potent, selective, and orally active 5-HT₄ receptor antagonist with a pK_i of 9.1 in guinea pig striatal membranes. RS 39604 displays a low affinity (pK_i<6.5) for 5-HT_1A, 5-HT_2C, 5-HT₃, α_1c, D₁, D₂, M₁, M₂, AT₁, B₁ and opioid mu receptors and moderate affinity for δ₁, (pK_i=6.8) and δ₂ (pK_i=7.8) sites.

For research use only. We do not sell to patients.

RS 39604 Chemical Structure

CAS No. : 167710-87-4

Size	Price	Stock
5 mg	USD 490	Ask For Quote & Lead Time
10 mg	USD 790	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

5-HT₄ Receptor

9.1 (pKi)

Molecular Weight

590.56

Formula

C₂₆H₃₇Cl₂N₃O₆S

CAS No.

167710-87-4

Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(NCCN1CCC(CCC(C2=CC(Cl)=C(N)C=C2OCC3=CC(OC)=CC(OC)=C3)=O)CC1)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (84.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6933 mL	8.4665 mL	16.9331 mL
5 mM	0.3387 mL	1.6933 mL	3.3866 mL
10 mM	0.1693 mL	0.8467 mL	1.6933 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (251 KB)

Handling Instructions (2659 KB)

References

[1]. Hegde SS, et al. RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist. Br J Pharmacol. 1995;115(6):1087-1095. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6933 mL	8.4665 mL	16.9331 mL	42.3327 mL
	5 mM	0.3387 mL	1.6933 mL	3.3866 mL	8.4665 mL
	10 mM	0.1693 mL	0.8467 mL	1.6933 mL	4.2333 mL
	15 mM	0.1129 mL	0.5644 mL	1.1289 mL	2.8222 mL
	20 mM	0.0847 mL	0.4233 mL	0.8467 mL	2.1166 mL
	25 mM	0.0677 mL	0.3387 mL	0.6773 mL	1.6933 mL
	30 mM	0.0564 mL	0.2822 mL	0.5644 mL	1.4111 mL
	40 mM	0.0423 mL	0.2117 mL	0.4233 mL	1.0583 mL
	50 mM	0.0339 mL	0.1693 mL	0.3387 mL	0.8467 mL
	60 mM	0.0282 mL	0.1411 mL	0.2822 mL	0.7055 mL
	80 mM	0.0212 mL	0.1058 mL	0.2117 mL	0.5292 mL

RS 39604 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RS 39604167710-87-4RS39604RS-396045-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorselectiveorally activelong-lastingvisceral paincolorectal distensionInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks