RU-TRAAK-2

Cat. No.: HY-117825 Purity: 99.72%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

RU-TRAAK-2 is a completely reversible TRAAK (TWIK-related arachidonic acid-stimulated K⁺ channel) inhibitor. RU-TRAAK-2 exerts no activity for non-K2P channels (Kv1.2, Slo1 and GIRK2). RU-TRAAK-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

RU-TRAAK-2 Chemical Structure

CAS No. : 1210538-56-9

Size	Price	Stock	Quantity
5 mg	USD 370	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 560	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 960	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1340	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1850	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

RU-TRAAK-2 is a completely reversible TRAAK (TWIK-related arachidonic acid-stimulated K⁺ channel) inhibitor. RU-TRAAK-2 exerts no activity for non-K2P channels (Kv1.2, Slo1 and GIRK2)^[1]. RU-TRAAK-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Molecular Weight

335.42

Formula

C₁₉H₁₇N₃OS

CAS No.

1210538-56-9

Appearance

Solid

Color

White to yellow

SMILES

O=C(NCC#CC1=CC=CC=C1)N(CC2=NC3=CC=CC=C3S2)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (149.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9813 mL	14.9067 mL	29.8134 mL
5 mM	0.5963 mL	2.9813 mL	5.9627 mL
10 mM	0.2981 mL	1.4907 mL	2.9813 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.72%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (246 KB) HNMR (264 KB) LCMS (266 KB)

Handling Instructions (2659 KB)

References

[1]. Su Z, et al. Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels. Proc Natl Acad Sci U S A. 2016;113(20):5748-5753. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9813 mL	14.9067 mL	29.8134 mL	74.5334 mL
	5 mM	0.5963 mL	2.9813 mL	5.9627 mL	14.9067 mL
	10 mM	0.2981 mL	1.4907 mL	2.9813 mL	7.4533 mL
	15 mM	0.1988 mL	0.9938 mL	1.9876 mL	4.9689 mL
	20 mM	0.1491 mL	0.7453 mL	1.4907 mL	3.7267 mL
	25 mM	0.1193 mL	0.5963 mL	1.1925 mL	2.9813 mL
	30 mM	0.0994 mL	0.4969 mL	0.9938 mL	2.4844 mL
	40 mM	0.0745 mL	0.3727 mL	0.7453 mL	1.8633 mL
	50 mM	0.0596 mL	0.2981 mL	0.5963 mL	1.4907 mL
	60 mM	0.0497 mL	0.2484 mL	0.4969 mL	1.2422 mL
	80 mM	0.0373 mL	0.1863 mL	0.3727 mL	0.9317 mL
	100 mM	0.0298 mL	0.1491 mL	0.2981 mL	0.7453 mL

RU-TRAAK-2 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RU-TRAAK-21210538-56-9Potassium ChannelKcsAreversibleTRAAK non-K2PchannelsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

RU-TRAAK-2

Customer Review

RU-TRAAK-2 Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

RU-TRAAK-2 Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report