2. Neuronal Signaling
  3. Imidazoline Receptor
  4. RX 801077 hydrochloride

RX 801077 hydrochloride  (Synonyms: 2 BFI)

Cat. No.: HY-100904 Purity: 99.82%
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RX 801077 hydrochloride (2 BFI) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 hydrochlorideshows anti-inflammation and neuroprotection. RX 801077 hydrochloride has the potential for the research of traumatic brain injury (TBI).

For research use only. We do not sell to patients.

RX 801077 hydrochloride Chemical Structure

RX 801077 hydrochloride Chemical Structure

CAS No. : 89196-95-2

Size Price Stock Quantity
5 mg USD 67 In-stock
10 mg USD 107 In-stock
25 mg USD 224 In-stock
50 mg USD 358 In-stock
100 mg USD 573 In-stock
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Based on 1 publication(s) in Google Scholar

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RX 801077 hydrochloride Related Antibodies

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Description

RX 801077 hydrochloride (2 BFI) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 hydrochlorideshows anti-inflammation and neuroprotection. RX 801077 hydrochloride has the potential for the research of traumatic brain injury (TBI)[1][2].

IC50 & Target

Ki: 70.1 nM (imidazoline I2 receptor)[1]
In Vivo

RX 801077 hydrochloride (5, 10, 20 mg/kg; i.p.; twice daily for 3 days) inhibits NLRP3 inflammasome-induced inflammation and necroptosis in a rat model of traumatic brain injury[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 280-300 g, Male adult Sprague-Dawley rats (TBI model)[2]
Dosage: 5, 10, 20 mg/kg
Administration: I.p.; twice daily for 3 days
Result: Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex.
Molecular Weight

222.67

Formula

C11H11ClN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

Cl[H].C1(C2=CC3=CC=CC=C3O2)=NCCN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (93.55 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4910 mL 22.4548 mL 44.9095 mL
5 mM 0.8982 mL 4.4910 mL 8.9819 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4910 mL 22.4548 mL 44.9095 mL 112.2738 mL
5 mM 0.8982 mL 4.4910 mL 8.9819 mL 22.4548 mL
10 mM 0.4491 mL 2.2455 mL 4.4910 mL 11.2274 mL
15 mM 0.2994 mL 1.4970 mL 2.9940 mL 7.4849 mL
20 mM 0.2245 mL 1.1227 mL 2.2455 mL 5.6137 mL
25 mM 0.1796 mL 0.8982 mL 1.7964 mL 4.4910 mL
30 mM 0.1497 mL 0.7485 mL 1.4970 mL 3.7425 mL
40 mM 0.1123 mL 0.5614 mL 1.1227 mL 2.8068 mL
50 mM 0.0898 mL 0.4491 mL 0.8982 mL 2.2455 mL
60 mM 0.0748 mL 0.3742 mL 0.7485 mL 1.8712 mL
80 mM 0.0561 mL 0.2807 mL 0.5614 mL 1.4034 mL
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RX 801077 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RX 80107789196-95-22 BFIRX801077RX-801077Imidazoline Receptoranti-inflammationnecroptosisRIP1RIP3IL-1βtraumatic brain injuryInhibitorinhibitorinhibit

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