RX 801077 (Synonyms: 2 BFI free base)

Cat. No.: HY-100904A: FAQs
Data Sheet Handling Instructions

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RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a K_i value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI).

For research use only. We do not sell to patients.

RX 801077 Chemical Structure

CAS No. : 72583-92-7

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Other Forms of RX 801077:

RX 801077-d4 hydrochloride Get quote
RX 801077 hydrochloride Get quote

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Description

IC₅₀ & Target

K_i: 70.1 nM (imidazoline I2 receptor)^[2]

In Vivo

RX 801077 (5, 10, 20 mg/kg; i.p.; twice daily for 3 days) inhibits NLRP3 inflammasome-induced inflammation and necroptosis in a rat model of traumatic brain injury^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	280-300 g, Male adult Sprague-Dawley rats (TBI model)^[2]
Dosage:	5, 10, 20 mg/kg
Administration:	I.p.; twice daily for 3 days
Result:	Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex.

Molecular Weight

186.21

Formula

C₁₁H₁₀N₂O

CAS No.

72583-92-7

SMILES

C1(C2=CC3=CC=CC=C3O2)=NCCN1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Carpéné C, et al. Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites. J Pharmacol Exp Ther. 1995 Feb;272(2):681-8. [Content Brief]

[2]. Ni H, et al. 2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury. Front Neurosci. 2019 Jun 26;13:674.

RX 801077 Related Classifications

Neurological Disease Inflammation/Immunology

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RX 80107772583-92-72 BFIRX801077RX-801077Imidazoline Receptoranti-inflammationnecroptosisRIP1RIP3IL-1βtraumatic brain injuryInhibitorinhibitorinhibit

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