(S)-3,4-DCPG (Synonyms: (S)-3,4-Dicarboxyphenylglycine)

Cat. No.: HY-107516: FAQs
Data Sheet SDS COA Handling Instructions

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(S)-3,4-DCPG is a selective agonist of metabotropic glutamate receptor 8a (mGluR8a) with an EC₅₀ of 31 nM in AV12-664 cells expressing human mGluR8.

For research use only. We do not sell to patients.

(S)-3,4-DCPG Chemical Structure

CAS No. : 201730-11-2

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5 mg	USD 540	Ask For Quote & Lead Time

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

Biological Activity
Purity & Documentation
References
Customer Review

Description

(S)-3,4-DCPG is a selective agonist of metabotropic glutamate receptor 8a (mGluR8a) with an EC₅₀ of 31 nM in AV12-664 cells expressing human mGluR8^[1].

IC₅₀ & Target

hmGluR8a

31 nM (EC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	< 100 μM Compound: 10	Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Active Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Active	[PMID: 15801843]
HEK293	EC₅₀	8.8 μM Compound: 10	Stimulation od [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells Stimulation od [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells	[PMID: 15801843]

Molecular Weight

239.18

Formula

C₁₀H₉NO₆

CAS No.

201730-11-2

Appearance

Solid

Color

White to off-white

SMILES

OC(C1=C(C=CC([C@H](N)C(O)=O)=C1)C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (83.62 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1810 mL	20.9048 mL	41.8095 mL
5 mM	0.8362 mL	4.1810 mL	8.3619 mL
10 mM	0.4181 mL	2.0905 mL	4.1810 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (250 KB) Elemental Analysis Report (108 KB)

Handling Instructions (2659 KB)

References

[1]. Thomas NK, et al. (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 Mar;40(3):311-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1810 mL	20.9048 mL	41.8095 mL	104.5238 mL
	5 mM	0.8362 mL	4.1810 mL	8.3619 mL	20.9048 mL
	10 mM	0.4181 mL	2.0905 mL	4.1810 mL	10.4524 mL
	15 mM	0.2787 mL	1.3937 mL	2.7873 mL	6.9683 mL
	20 mM	0.2090 mL	1.0452 mL	2.0905 mL	5.2262 mL
	25 mM	0.1672 mL	0.8362 mL	1.6724 mL	4.1810 mL
	30 mM	0.1394 mL	0.6968 mL	1.3937 mL	3.4841 mL
	40 mM	0.1045 mL	0.5226 mL	1.0452 mL	2.6131 mL
	50 mM	0.0836 mL	0.4181 mL	0.8362 mL	2.0905 mL
	60 mM	0.0697 mL	0.3484 mL	0.6968 mL	1.7421 mL
	80 mM	0.0523 mL	0.2613 mL	0.5226 mL	1.3065 mL

(S)-3,4-DCPG Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-3,4-DCPG201730-11-2(S)-3,4-DicarboxyphenylglycinemGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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