2. PROTAC
  3. PROTAC Linkers
  4. S-acetyl-PEG4-amine TFA

S-acetyl-PEG4-amine (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

S-acetyl-PEG4-amine TFA Chemical Structure

S-acetyl-PEG4-amine TFA Chemical Structure

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10 mg USD 125 In-stock
25 mg USD 250 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of S-acetyl-PEG4-amine TFA:

S-acetyl-PEG4-amine TFA Related Antibodies

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Description

S-acetyl-PEG4-amine (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S-acetyl-PEG4-amine TFA Related Antibodies
Molecular Weight

409.42

Formula

C14H26F3NO7S
Appearance

Oil

Color

Light brown to brown

SMILES

CC(SCCOCCOCCOCCOCCN)=O.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (305.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4425 mL 12.2124 mL 24.4248 mL
5 mM 0.4885 mL 2.4425 mL 4.8850 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4425 mL 12.2124 mL 24.4248 mL 61.0620 mL
5 mM 0.4885 mL 2.4425 mL 4.8850 mL 12.2124 mL
10 mM 0.2442 mL 1.2212 mL 2.4425 mL 6.1062 mL
15 mM 0.1628 mL 0.8142 mL 1.6283 mL 4.0708 mL
20 mM 0.1221 mL 0.6106 mL 1.2212 mL 3.0531 mL
25 mM 0.0977 mL 0.4885 mL 0.9770 mL 2.4425 mL
30 mM 0.0814 mL 0.4071 mL 0.8142 mL 2.0354 mL
40 mM 0.0611 mL 0.3053 mL 0.6106 mL 1.5265 mL
50 mM 0.0488 mL 0.2442 mL 0.4885 mL 1.2212 mL
60 mM 0.0407 mL 0.2035 mL 0.4071 mL 1.0177 mL
80 mM 0.0305 mL 0.1527 mL 0.3053 mL 0.7633 mL
100 mM 0.0244 mL 0.1221 mL 0.2442 mL 0.6106 mL
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S-acetyl-PEG4-amine TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-acetyl-PEG4-aminePROTAC LinkersPEGPROTAC linkeractive compoundsynthesisInhibitorinhibitorinhibit

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