2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. (S)-AMPA

(S)-AMPA (L-AMPA), an active S-enantiomer of AMPA, is a potent and selective AMPA receptor agonist.

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(S)-AMPA Chemical Structure

(S)-AMPA Chemical Structure

CAS No. : 83643-88-3

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5 mg USD 340 In-stock
10 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (S)-AMPA:

(S)-AMPA Related Antibodies

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description

(S)-AMPA (L-AMPA), an active S-enantiomer of AMPA, is a potent and selective AMPA receptor agonist[1][2].

In Vitro

Superfusion of (S)-AMPA (1 μM) significantly attenuates CGRP release in a CB1-dependent manner[3].
24-h exposure to (S)-AMPA (0.01-1000 μM) induces concentration-dependent neuronal cell death (EC50 of 3 μM) with cellular changes including neurite blebbing, chromatin condensation, and DNA fragmentation, indicative of apoptosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-AMPA Related Antibodies
Molecular Weight

186.17

Formula

C7H10N2O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C(C[C@H](N)C(O)=O)=C(C)ON1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 18.7 mg/mL (100.45 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3714 mL 26.8572 mL 53.7143 mL
5 mM 1.0743 mL 5.3714 mL 10.7429 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99%

COA (251 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.3714 mL 26.8572 mL 53.7143 mL 134.2859 mL
5 mM 1.0743 mL 5.3714 mL 10.7429 mL 26.8572 mL
10 mM 0.5371 mL 2.6857 mL 5.3714 mL 13.4286 mL
15 mM 0.3581 mL 1.7905 mL 3.5810 mL 8.9524 mL
20 mM 0.2686 mL 1.3429 mL 2.6857 mL 6.7143 mL
25 mM 0.2149 mL 1.0743 mL 2.1486 mL 5.3714 mL
30 mM 0.1790 mL 0.8952 mL 1.7905 mL 4.4762 mL
40 mM 0.1343 mL 0.6714 mL 1.3429 mL 3.3571 mL
50 mM 0.1074 mL 0.5371 mL 1.0743 mL 2.6857 mL
60 mM 0.0895 mL 0.4476 mL 0.8952 mL 2.2381 mL
80 mM 0.0671 mL 0.3357 mL 0.6714 mL 1.6786 mL
100 mM 0.0537 mL 0.2686 mL 0.5371 mL 1.3429 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(S)-AMPA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-AMPA83643-88-3L-AMPAiGluRIonotropic glutamate receptorsAMPAS-enantiomerCB1Inhibitorinhibitorinhibit

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