(S)-AMPA (Synonyms: L-AMPA)

Name: (S)-AMPA
Brand: MedChemExpress
SKU: HY-100815A
Rating: 4.5 (1 reviews)

Cat. No.: HY-100815A Purity: ≥99%: FAQs
Data Sheet SDS COA Handling Instructions

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(S)-AMPA (L-AMPA), an active S-enantiomer of AMPA, is a potent and selective AMPA receptor agonist.

For research use only. We do not sell to patients.

(S)-AMPA Chemical Structure

CAS No. : 83643-88-3

Size	Price	Stock	Quantity
5 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (S)-AMPA:

(R)-AMPA Get quote
(RS)-AMPA monohydrate Get quote

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AMPA Receptor NMDA Receptor Kainate Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

(S)-AMPA (L-AMPA), an active S-enantiomer of AMPA, is a potent and selective AMPA receptor agonist^[1]^[2].

In Vitro

Superfusion of (S)-AMPA (1 μM) significantly attenuates CGRP release in a CB1-dependent manner^[3].
24-h exposure to (S)-AMPA (0.01-1000 μM) induces concentration-dependent neuronal cell death (EC₅₀ of 3 μM) with cellular changes including neurite blebbing, chromatin condensation, and DNA fragmentation, indicative of apoptosis^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

186.17

Formula

C₇H₁₀N₂O₄

CAS No.

83643-88-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C(C[C@H](N)C(O)=O)=C(C)ON1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 18.7 mg/mL (100.45 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.3714 mL	26.8572 mL	53.7143 mL
5 mM	1.0743 mL	5.3714 mL	10.7429 mL
10 mM	0.5371 mL	2.6857 mL	5.3714 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (251 KB)

Handling Instructions (2659 KB)

References

[1]. J A Larm, et al. (S)-5-fluorowillardiine-mediated neurotoxicity in cultured murine cortical neurones occurs via AMPA and kainate receptors. Eur J Pharmacol. 1996 Oct 24;314(1-2):249-54. [Content Brief]

[2]. B Ebert, et al. Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA. Neurochem Int. 1994 Jun;24(6):507-15. [Content Brief]

[3]. J W Brooks, et al. (S)-AMPA inhibits electrically evoked calcitonin gene-related peptide (CGRP) release from the rat dorsal horn: reversal by cannabinoid receptor antagonist SR141716A. Neurosci Lett. 2004 Nov 30;372(1-2):85-8. [Content Brief]

[4]. J A Larm, et al. Apoptosis induced via AMPA-selective glutamate receptors in cultured murine cortical neurons. J Neurochem. 1997 Aug;69(2):617-22. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.3714 mL	26.8572 mL	53.7143 mL	134.2859 mL
	5 mM	1.0743 mL	5.3714 mL	10.7429 mL	26.8572 mL
	10 mM	0.5371 mL	2.6857 mL	5.3714 mL	13.4286 mL
	15 mM	0.3581 mL	1.7905 mL	3.5810 mL	8.9524 mL
	20 mM	0.2686 mL	1.3429 mL	2.6857 mL	6.7143 mL
	25 mM	0.2149 mL	1.0743 mL	2.1486 mL	5.3714 mL
	30 mM	0.1790 mL	0.8952 mL	1.7905 mL	4.4762 mL
	40 mM	0.1343 mL	0.6714 mL	1.3429 mL	3.3571 mL
	50 mM	0.1074 mL	0.5371 mL	1.0743 mL	2.6857 mL
	60 mM	0.0895 mL	0.4476 mL	0.8952 mL	2.2381 mL
	80 mM	0.0671 mL	0.3357 mL	0.6714 mL	1.6786 mL
	100 mM	0.0537 mL	0.2686 mL	0.5371 mL	1.3429 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

(S)-AMPA Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-AMPA83643-88-3L-AMPAiGluRIonotropic glutamate receptorsAMPAS-enantiomerCB1Inhibitorinhibitorinhibit

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(S)-AMPA (Synonyms: L-AMPA)

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Other Forms of (S)-AMPA:

(S)-AMPA Related Antibodies

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References

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(S)-AMPA Related Antibodies

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Complete Stock Solution Preparation Table

(S)-AMPA Related Classifications

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