1. PI3K/Akt/mTOR
  2. PI3K
  3. (S)-AZD 6482

(S)-AZD6482 ((S)-KIN-193) is a highly effective and selective ATP-competitive inhibitor of PI3Kβ, exhibiting an IC(50) of 0.01 μM, and it can reduce insulin-induced glucose uptake by human adipocytes in vitro with an IC(50) of 4.4 μM.

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(S)-AZD 6482 Chemical Structure

(S)-AZD 6482 Chemical Structure

CAS No. : 1173900-37-2

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Description

(S)-AZD6482 ((S)-KIN-193) is a highly effective and selective ATP-competitive inhibitor of PI3Kβ, exhibiting an IC(50) of 0.01 μM, and it can reduce insulin-induced glucose uptake by human adipocytes in vitro with an IC(50) of 4.4 μM.

Molecular Weight

408.45

Formula

C22H24N4O4

CAS No.
SMILES

O=C(C1=CC=CC=C1N[C@@H](C)C2=CC(C)=CN3C2=NC(N4CCOCC4)=CC3=O)O

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(S)-AZD 6482 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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(S)-AZD 6482
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HY-118236
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