2. Epigenetics
  3. Epigenetic Reader Domain
  4. (S)-GSK852

(S)-GSK852 is a diastereomer of GSK852 (HY-115867). GSK852 is a BET inhibitor targeting BD2 (pIC50=7.9).

For research use only. We do not sell to patients.

(S)-GSK852 Chemical Structure

(S)-GSK852 Chemical Structure

CAS No. : 2305919-51-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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5 mg In-stock
10 mg In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (S)-GSK852:

(S)-GSK852 Related Antibodies

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Description

(S)-GSK852 is a diastereomer of GSK852 (HY-115867). GSK852 is a BET inhibitor targeting BD2 (pIC50=7.9)[1].

Molecular Weight

406.47

Formula

C24H26N2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(C(NC)=O)=C2OC[C@](C3=CC=CC=C3)(C)C2=C1)N[C@H]4[C@]5([H])C[C@H](O)C[C@@]54[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (246.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4602 mL 12.3010 mL 24.6021 mL
5 mM 0.4920 mL 2.4602 mL 4.9204 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4602 mL 12.3010 mL 24.6021 mL 61.5052 mL
5 mM 0.4920 mL 2.4602 mL 4.9204 mL 12.3010 mL
10 mM 0.2460 mL 1.2301 mL 2.4602 mL 6.1505 mL
15 mM 0.1640 mL 0.8201 mL 1.6401 mL 4.1003 mL
20 mM 0.1230 mL 0.6151 mL 1.2301 mL 3.0753 mL
25 mM 0.0984 mL 0.4920 mL 0.9841 mL 2.4602 mL
30 mM 0.0820 mL 0.4100 mL 0.8201 mL 2.0502 mL
40 mM 0.0615 mL 0.3075 mL 0.6151 mL 1.5376 mL
50 mM 0.0492 mL 0.2460 mL 0.4920 mL 1.2301 mL
60 mM 0.0410 mL 0.2050 mL 0.4100 mL 1.0251 mL
80 mM 0.0308 mL 0.1538 mL 0.3075 mL 0.7688 mL
100 mM 0.0246 mL 0.1230 mL 0.2460 mL 0.6151 mL
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(S)-GSK852 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-GSK8522305919-51-9Epigenetic Reader DomainDiastereomersInhibitorinhibitorinhibit

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