2. Immunology/Inflammation
  3. COX
  4. (S)-(+)-Ibuprofen-d3

(S)-(+)-Ibuprofen-d3  (Synonyms: (S)-Ibuprofen d3)

Cat. No.: HY-78131AS Purity: 98.87%
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(S)-(+)-Ibuprofen-d3 is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].

For research use only. We do not sell to patients.

(S)-(+)-Ibuprofen-d<sub>3</sub> Chemical Structure

(S)-(+)-Ibuprofen-d3 Chemical Structure

CAS No. : 1329643-44-8

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1 mg USD 580 In-stock
5 mg USD 1620 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (S)-(+)-Ibuprofen-d3:

(S)-(+)-Ibuprofen-d3 Related Antibodies

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COX COX-1 COX-2 COX-3

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Description

(S)-(+)-Ibuprofen-d3 is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen that inhibits COX-1 and COX-2 activity with IC50s of 2.1 μM and 1.6 μM. (S)-(+)-Ibuprofen has analgesic, antiinflammatory and antipyretic effects[1][2].

IC50 & Target[1]

COX-1

2.1 μM (IC50)

COX-2

1.6 μM (IC50)

Molecular Weight

209.30

Formula

C13H15D3O2
CAS No.
Unlabeled CAS

51146-56-6
Appearance

Solid

Color

White to off-white

SMILES

OC([C@H](C1=CC=C(CC(C)C)C=C1)C([2H])([2H])[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (477.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 100 mg/mL (477.78 mM; Need ultrasonic)

Ethanol : 100 mg/mL (477.78 mM; Need ultrasonic)

DMSO : 100 mg/mL (477.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7778 mL 23.8892 mL 47.7783 mL
5 mM 0.9556 mL 4.7778 mL 9.5557 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol / Ethanol / DMSO 1 mM 4.7778 mL 23.8892 mL 47.7783 mL 119.4458 mL
5 mM 0.9556 mL 4.7778 mL 9.5557 mL 23.8892 mL
10 mM 0.4778 mL 2.3889 mL 4.7778 mL 11.9446 mL
15 mM 0.3185 mL 1.5926 mL 3.1852 mL 7.9631 mL
20 mM 0.2389 mL 1.1945 mL 2.3889 mL 5.9723 mL
25 mM 0.1911 mL 0.9556 mL 1.9111 mL 4.7778 mL
30 mM 0.1593 mL 0.7963 mL 1.5926 mL 3.9815 mL
40 mM 0.1194 mL 0.5972 mL 1.1945 mL 2.9861 mL
50 mM 0.0956 mL 0.4778 mL 0.9556 mL 2.3889 mL
60 mM 0.0796 mL 0.3982 mL 0.7963 mL 1.9908 mL
80 mM 0.0597 mL 0.2986 mL 0.5972 mL 1.4931 mL
100 mM 0.0478 mL 0.2389 mL 0.4778 mL 1.1945 mL
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(S)-(+)-Ibuprofen-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-(+)-Ibuprofen-d31329643-44-8(S)-Ibuprofen d3COXCyclooxygenaseDeuteriumlabeledenantiomerCOX-1COX-2analgesicanti-inflammatoryantipyreticInhibitorinhibitorinhibit

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