(S)-LTGO-33

Cat. No.: HY-157802A Purity: 99.41%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

(S)-LTGO-33 is a small molecule inhibitor of voltage-gated sodium channel NaV1.8. (S)-LTGO-33 can be used in the treatment of pain disorders.

For research use only. We do not sell to patients.

(S)-LTGO-33 Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of (S)-LTGO-33:

LTGO-33 Get quote

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View All Sodium Channel Isoform Specific Products:

View All Isoforms

Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8

Biological Activity
Purity & Documentation
References
Customer Review

Description

(S)-LTGO-33 is a small molecule inhibitor of voltage-gated sodium channel NaV1.8. (S)-LTGO-33 can be used in the treatment of pain disorders^[1].

Molecular Weight

467.44

Formula

C₂₁H₁₇F₄N₃O₃S

Appearance

Solid

Color

Off-white to light yellow

SMILES

FC1=CC(C)=C(OC2=NC=C(C=C2C(NC3=CC=CC([S@@](=O)(C)=N)=C3)=O)C(F)(F)F)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (427.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1393 mL	10.6966 mL	21.3931 mL
5 mM	0.4279 mL	2.1393 mL	4.2786 mL
10 mM	0.2139 mL	1.0697 mL	2.1393 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.41%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (253 KB) HNMR (271 KB) LCMS (112 KB)

Handling Instructions (2659 KB)

References

[1]. Gilchrist JM, et al. Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1.8 with a Unique Mechanism of Action. Mol Pharmacol. 2024 Feb 15;105(3):233-249. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1393 mL	10.6966 mL	21.3931 mL	53.4828 mL
	5 mM	0.4279 mL	2.1393 mL	4.2786 mL	10.6966 mL
	10 mM	0.2139 mL	1.0697 mL	2.1393 mL	5.3483 mL
	15 mM	0.1426 mL	0.7131 mL	1.4262 mL	3.5655 mL
	20 mM	0.1070 mL	0.5348 mL	1.0697 mL	2.6741 mL
	25 mM	0.0856 mL	0.4279 mL	0.8557 mL	2.1393 mL
	30 mM	0.0713 mL	0.3566 mL	0.7131 mL	1.7828 mL
	40 mM	0.0535 mL	0.2674 mL	0.5348 mL	1.3371 mL
	50 mM	0.0428 mL	0.2139 mL	0.4279 mL	1.0697 mL
	60 mM	0.0357 mL	0.1783 mL	0.3566 mL	0.8914 mL
	80 mM	0.0267 mL	0.1337 mL	0.2674 mL	0.6685 mL
	100 mM	0.0214 mL	0.1070 mL	0.2139 mL	0.5348 mL

(S)-LTGO-33 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-LTGO-33Sodium ChannelNa channelsNa+ channelspain disordersVSDIIcynomolgus monkeyDRG neuronsInhibitorinhibitorinhibit

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