(S)-OTS514

Cat. No.: HY-18621B: FAQs
Data Sheet Handling Instructions

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(S)-OTS514 is the S enantiomer of OTS514 (HY-18621). OTS514 is a highly potent TOPK inhibitor with an IC₅₀ of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells. OTS514 induces cell cycle arrest and apoptosis.

For research use only. We do not sell to patients.

(S)-OTS514 Chemical Structure

CAS No. : 1338541-25-5

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Other Forms of (S)-OTS514:

OTS514 In-stock
OTS514 hydrochloride Get quote

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Description

(S)-OTS514 is the S enantiomer of OTS514 (HY-18621). OTS514 is a highly potent TOPK inhibitor with an IC₅₀ of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells^[1]. OTS514 induces cell cycle arrest and apoptosis^[2].

Molecular Weight

364.46

Formula

C₂₁H₂₀N₂O₂S

CAS No.

1338541-25-5

SMILES

O=C1NC2=C(C(C3=CC=C([C@H](C)CN)C=C3)=C(O)C=C2C)C4=C1SC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 31.43 mg/mL (86.24 mM; adjust pH to 3 with 1 M HCL; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7438 mL	13.7189 mL	27.4379 mL
5 mM	0.5488 mL	2.7438 mL	5.4876 mL
10 mM	0.2744 mL	1.3719 mL	2.7438 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Matsuo Y, et al. TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. Sci Transl Med. 2014 Oct 22;6(259):259ra145. [Content Brief]

[2]. Stefka AT, et al. Potent anti-myeloma activity of the TOPK inhibitor OTS514 in pre-clinical models. Cancer Med. 2020 Jan;9(1):324-334. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7438 mL	13.7189 mL	27.4379 mL	68.5946 mL
	5 mM	0.5488 mL	2.7438 mL	5.4876 mL	13.7189 mL
	10 mM	0.2744 mL	1.3719 mL	2.7438 mL	6.8595 mL
	15 mM	0.1829 mL	0.9146 mL	1.8292 mL	4.5730 mL
	20 mM	0.1372 mL	0.6859 mL	1.3719 mL	3.4297 mL
	25 mM	0.1098 mL	0.5488 mL	1.0975 mL	2.7438 mL
	30 mM	0.0915 mL	0.4573 mL	0.9146 mL	2.2865 mL
	40 mM	0.0686 mL	0.3430 mL	0.6859 mL	1.7149 mL
	50 mM	0.0549 mL	0.2744 mL	0.5488 mL	1.3719 mL
	60 mM	0.0457 mL	0.2286 mL	0.4573 mL	1.1432 mL
	80 mM	0.0343 mL	0.1715 mL	0.3430 mL	0.8574 mL

(S)-OTS514 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-OTS5141338541-25-5TOPKApoptosisT-LAK cell-originated protein kinaseenantiomerInhibitorinhibitorinhibit

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