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  4. (S)-OTS514

(S)-OTS514 is the S enantiomer of OTS514 (HY-18621). OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells. OTS514 induces cell cycle arrest and apoptosis.

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(S)-OTS514 Chemical Structure

(S)-OTS514 Chemical Structure

CAS No. : 1338541-25-5

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(S)-OTS514 Related Antibodies

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Description

(S)-OTS514 is the S enantiomer of OTS514 (HY-18621). OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells[1]. OTS514 induces cell cycle arrest and apoptosis[2].

Molecular Weight

364.46

Formula

C21H20N2O2S
CAS No.
SMILES

O=C1NC2=C(C(C3=CC=C([C@H](C)CN)C=C3)=C(O)C=C2C)C4=C1SC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 31.43 mg/mL (86.24 mM; adjust pH to 3 with 1 M HCL; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7438 mL 13.7189 mL 27.4379 mL
5 mM 0.5488 mL 2.7438 mL 5.4876 mL
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7438 mL 13.7189 mL 27.4379 mL 68.5946 mL
5 mM 0.5488 mL 2.7438 mL 5.4876 mL 13.7189 mL
10 mM 0.2744 mL 1.3719 mL 2.7438 mL 6.8595 mL
15 mM 0.1829 mL 0.9146 mL 1.8292 mL 4.5730 mL
20 mM 0.1372 mL 0.6859 mL 1.3719 mL 3.4297 mL
25 mM 0.1098 mL 0.5488 mL 1.0975 mL 2.7438 mL
30 mM 0.0915 mL 0.4573 mL 0.9146 mL 2.2865 mL
40 mM 0.0686 mL 0.3430 mL 0.6859 mL 1.7149 mL
50 mM 0.0549 mL 0.2744 mL 0.5488 mL 1.3719 mL
60 mM 0.0457 mL 0.2286 mL 0.4573 mL 1.1432 mL
80 mM 0.0343 mL 0.1715 mL 0.3430 mL 0.8574 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-OTS5141338541-25-5OthersenantiomerInhibitorinhibitorinhibit

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