2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-amido-C5-acid

(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180).

For research use only. We do not sell to patients.

(S,R,S)-AHPC-amido-C5-acid Chemical Structure

(S,R,S)-AHPC-amido-C5-acid Chemical Structure

CAS No. : 2162120-87-6

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Based on 1 publication(s) in Google Scholar

(S,R,S)-AHPC-amido-C5-acid Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

(S,R,S)-AHPC-amido-C5-acid incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design XY028-133 (HY-129180)[1].

IC50 & Target[1]

VHL

 

Molecular Weight

572.72

Formula

C29H40N4O6S
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C([C@H]1N(C[C@@H](C1)O)C([C@@H](NC(CCCCCC(O)=O)=O)C(C)(C)C)=O)NCC2=CC=C(C=C2)C3=C(N=CS3)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (174.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7461 mL 8.7303 mL 17.4605 mL
5 mM 0.3492 mL 1.7461 mL 3.4921 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7461 mL 8.7303 mL 17.4605 mL 43.6514 mL
5 mM 0.3492 mL 1.7461 mL 3.4921 mL 8.7303 mL
10 mM 0.1746 mL 0.8730 mL 1.7461 mL 4.3651 mL
15 mM 0.1164 mL 0.5820 mL 1.1640 mL 2.9101 mL
20 mM 0.0873 mL 0.4365 mL 0.8730 mL 2.1826 mL
25 mM 0.0698 mL 0.3492 mL 0.6984 mL 1.7461 mL
30 mM 0.0582 mL 0.2910 mL 0.5820 mL 1.4550 mL
40 mM 0.0437 mL 0.2183 mL 0.4365 mL 1.0913 mL
50 mM 0.0349 mL 0.1746 mL 0.3492 mL 0.8730 mL
60 mM 0.0291 mL 0.1455 mL 0.2910 mL 0.7275 mL
80 mM 0.0218 mL 0.1091 mL 0.2183 mL 0.5456 mL
100 mM 0.0175 mL 0.0873 mL 0.1746 mL 0.4365 mL
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(S,R,S)-AHPC-amido-C5-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-amido-C5-acid2162120-87-6E3 Ligase Ligand-Linker ConjugatesbreastcancerligandE3tumorInhibitorinhibitorinhibit

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