2. Metabolic Enzyme/Protease NF-κB
  3. MALT1
  4. (S,R,S)-AHPC-Boc derivative 1

(S,R,S)-AHPC-Boc derivative 1  (Synonyms: VH032-Boc derivative 1)

Cat. No.: HY-173097
Handling Instructions Technical Support

(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1, leading to ubiquitination and subsequent proteasomal degradation of MALT1. (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway by disrupting the CBM complex, demonstrating potential for inducing apoptosis in ABC-DLBCL cells. (S,R,S)-AHPC-Boc derivative 1 is promising for research of MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).

For research use only. We do not sell to patients.

(S,R,S)-AHPC-Boc derivative 1 Chemical Structure

(S,R,S)-AHPC-Boc derivative 1 Chemical Structure

CAS No. : 2086298-33-9

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Description

(S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1, leading to ubiquitination and subsequent proteasomal degradation of MALT1. (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway by disrupting the CBM complex, demonstrating potential for inducing apoptosis in ABC-DLBCL cells. (S,R,S)-AHPC-Boc derivative 1 is promising for research of MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL)[1].

Molecular Weight

560.71

Formula

C28H40N4O6S
CAS No.
SMILES

CC(C)(C)OC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)CO)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (89.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7835 mL 8.9173 mL 17.8345 mL
5 mM 0.3567 mL 1.7835 mL 3.5669 mL
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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7835 mL 8.9173 mL 17.8345 mL 44.5863 mL
5 mM 0.3567 mL 1.7835 mL 3.5669 mL 8.9173 mL
10 mM 0.1783 mL 0.8917 mL 1.7835 mL 4.4586 mL
15 mM 0.1189 mL 0.5945 mL 1.1890 mL 2.9724 mL
20 mM 0.0892 mL 0.4459 mL 0.8917 mL 2.2293 mL
25 mM 0.0713 mL 0.3567 mL 0.7134 mL 1.7835 mL
30 mM 0.0594 mL 0.2972 mL 0.5945 mL 1.4862 mL
40 mM 0.0446 mL 0.2229 mL 0.4459 mL 1.1147 mL
50 mM 0.0357 mL 0.1783 mL 0.3567 mL 0.8917 mL
60 mM 0.0297 mL 0.1486 mL 0.2972 mL 0.7431 mL
80 mM 0.0223 mL 0.1115 mL 0.2229 mL 0.5573 mL
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(S,R,S)-AHPC-Boc derivative 1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-Boc derivative 12086298-33-9VH032-Boc derivative 1MALT1mucosa associated lymphoid tissue lymphoma translocation gene 1NF-κB signaling pathwayDLBCLInhibitorinhibitorinhibit

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