2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-C1-NH2 hydrochloride

(S,R,S)-AHPC-C1-NH2 hydrochloride 

Cat. No.: HY-138861A Purity: 98.08%
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(S,R,S)-AHPC-C1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-C1-NH2 hydrochloride Chemical Structure

(S,R,S)-AHPC-C1-NH2 hydrochloride Chemical Structure

CAS No. : 2361120-26-3

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25 mg USD 70 In-stock
50 mg USD 115 In-stock
100 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (S,R,S)-AHPC-C1-NH2 hydrochloride:

(S,R,S)-AHPC-C1-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

  • Biological Activity

  • Purity & Documentation

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Description

(S,R,S)-AHPC-C1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology[1].

IC50 & Target

VHL

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-C1-NH2 hydrochloride Related Antibodies
Molecular Weight

524.08

Formula

C24H34ClN5O4S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (238.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9081 mL 9.5405 mL 19.0811 mL
5 mM 0.3816 mL 1.9081 mL 3.8162 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9081 mL 9.5405 mL 19.0811 mL 47.7026 mL
5 mM 0.3816 mL 1.9081 mL 3.8162 mL 9.5405 mL
10 mM 0.1908 mL 0.9541 mL 1.9081 mL 4.7703 mL
15 mM 0.1272 mL 0.6360 mL 1.2721 mL 3.1802 mL
20 mM 0.0954 mL 0.4770 mL 0.9541 mL 2.3851 mL
25 mM 0.0763 mL 0.3816 mL 0.7632 mL 1.9081 mL
30 mM 0.0636 mL 0.3180 mL 0.6360 mL 1.5901 mL
40 mM 0.0477 mL 0.2385 mL 0.4770 mL 1.1926 mL
50 mM 0.0382 mL 0.1908 mL 0.3816 mL 0.9541 mL
60 mM 0.0318 mL 0.1590 mL 0.3180 mL 0.7950 mL
80 mM 0.0239 mL 0.1193 mL 0.2385 mL 0.5963 mL
100 mM 0.0191 mL 0.0954 mL 0.1908 mL 0.4770 mL
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(S,R,S)-AHPC-C1-NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-C1-NH22361120-26-3E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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