(S,R,S)-AHPC-isobutyl acetate-methanesulfonothioate-Me-C10-NH2 TFA

Cat. No.: HY-138553A Purity: 98.86%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

(S,R,S)-AHPC-isobutyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is a part of PROTAC BRD4 Degrader-12 (HY-138635).

For research use only. We do not sell to patients.

(S,R,S)-AHPC-isobutyl acetate-methanesulfonothioate-Me-C10-NH2 TFA Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

(S,R,S)-AHPC-isobutyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is a part of PROTAC BRD4 Degrader-12 (HY-138635)^[1].

Molecular Weight

924.12

Formula

C₄₀H₆₀F₃N₅O₁₀S₃

Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(S[C@@H](COC(O[C@H](C1)CN(C([C@@H](NC(CCCCCCCCCCN)=O)C(C)(C)C)=O)[C@@H]1C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)=O)C)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (108.21 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0821 mL	5.4106 mL	10.8211 mL
5 mM	0.2164 mL	1.0821 mL	2.1642 mL
10 mM	0.1082 mL	0.5411 mL	1.0821 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.86%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (250 KB) HNMR (363 KB) LCMS (105 KB)

Handling Instructions (2659 KB)

References

[1]. Dragovich PS, et al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0821 mL	5.4106 mL	10.8211 mL	27.0528 mL
	5 mM	0.2164 mL	1.0821 mL	2.1642 mL	5.4106 mL
	10 mM	0.1082 mL	0.5411 mL	1.0821 mL	2.7053 mL
	15 mM	0.0721 mL	0.3607 mL	0.7214 mL	1.8035 mL
	20 mM	0.0541 mL	0.2705 mL	0.5411 mL	1.3526 mL
	25 mM	0.0433 mL	0.2164 mL	0.4328 mL	1.0821 mL
	30 mM	0.0361 mL	0.1804 mL	0.3607 mL	0.9018 mL
	40 mM	0.0271 mL	0.1353 mL	0.2705 mL	0.6763 mL
	50 mM	0.0216 mL	0.1082 mL	0.2164 mL	0.5411 mL
	60 mM	0.0180 mL	0.0902 mL	0.1804 mL	0.4509 mL
	80 mM	0.0135 mL	0.0676 mL	0.1353 mL	0.3382 mL
	100 mM	0.0108 mL	0.0541 mL	0.1082 mL	0.2705 mL