2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-Me-C10-Br

(S,R,S)-AHPC-Me-C10-Br is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-Me-C10-Br incorporates a VHL E3 ligase linker and MS432 based on the MEK1/2 inhibitor PD0325901.

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(S,R,S)-AHPC-Me-C10-Br Chemical Structure

(S,R,S)-AHPC-Me-C10-Br Chemical Structure

CAS No. : 2836297-55-1

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Based on 1 publication(s) in Google Scholar

(S,R,S)-AHPC-Me-C10-Br Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

(S,R,S)-AHPC-Me-C10-Br is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-Me-C10-Br incorporates a VHL E3 ligase linker and MS432 based on the MEK1/2 inhibitor PD0325901[1].

IC50 & Target[1]

VHL

 

Molecular Weight

691.76

Formula

C34H51BrN4O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@@H](NC(CCCCCCCCCCBr)=O)C(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (144.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4456 mL 7.2279 mL 14.4559 mL
5 mM 0.2891 mL 1.4456 mL 2.8912 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4456 mL 7.2279 mL 14.4559 mL 36.1397 mL
5 mM 0.2891 mL 1.4456 mL 2.8912 mL 7.2279 mL
10 mM 0.1446 mL 0.7228 mL 1.4456 mL 3.6140 mL
15 mM 0.0964 mL 0.4819 mL 0.9637 mL 2.4093 mL
20 mM 0.0723 mL 0.3614 mL 0.7228 mL 1.8070 mL
25 mM 0.0578 mL 0.2891 mL 0.5782 mL 1.4456 mL
30 mM 0.0482 mL 0.2409 mL 0.4819 mL 1.2047 mL
40 mM 0.0361 mL 0.1807 mL 0.3614 mL 0.9035 mL
50 mM 0.0289 mL 0.1446 mL 0.2891 mL 0.7228 mL
60 mM 0.0241 mL 0.1205 mL 0.2409 mL 0.6023 mL
80 mM 0.0181 mL 0.0903 mL 0.1807 mL 0.4517 mL
100 mM 0.0145 mL 0.0723 mL 0.1446 mL 0.3614 mL
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(S,R,S)-AHPC-Me-C10-Br Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-Me-C10-Br2836297-55-1E3 Ligase Ligand-Linker Conjugatesligand-linkerconjugateInhibitorinhibitorinhibit

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