2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-Me-C6-NH2

(S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTAC. (S,R,S)-AHPC-Me-C6-NH2 (Compound SI-9) contains VHL ligand 2 (HY-112078).

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(S,R,S)-AHPC-Me-C6-NH2 Chemical Structure

(S,R,S)-AHPC-Me-C6-NH2 Chemical Structure

CAS No. : 2411422-49-4

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Based on 1 publication(s) in Google Scholar

(S,R,S)-AHPC-Me-C6-NH2 Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

(S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTAC[1]. (S,R,S)-AHPC-Me-C6-NH2 (Compound SI-9) contains VHL ligand 2 (HY-112078)[2].

Molecular Weight

571.77

Formula

C30H45N5O4S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NCCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (174.90 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7490 mL 8.7448 mL 17.4895 mL
5 mM 0.3498 mL 1.7490 mL 3.4979 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7490 mL 8.7448 mL 17.4895 mL 43.7239 mL
5 mM 0.3498 mL 1.7490 mL 3.4979 mL 8.7448 mL
10 mM 0.1749 mL 0.8745 mL 1.7490 mL 4.3724 mL
15 mM 0.1166 mL 0.5830 mL 1.1660 mL 2.9149 mL
20 mM 0.0874 mL 0.4372 mL 0.8745 mL 2.1862 mL
25 mM 0.0700 mL 0.3498 mL 0.6996 mL 1.7490 mL
30 mM 0.0583 mL 0.2915 mL 0.5830 mL 1.4575 mL
40 mM 0.0437 mL 0.2186 mL 0.4372 mL 1.0931 mL
50 mM 0.0350 mL 0.1749 mL 0.3498 mL 0.8745 mL
60 mM 0.0291 mL 0.1457 mL 0.2915 mL 0.7287 mL
80 mM 0.0219 mL 0.1093 mL 0.2186 mL 0.5465 mL
100 mM 0.0175 mL 0.0874 mL 0.1749 mL 0.4372 mL
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(S,R,S)-AHPC-Me-C6-NH2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-Me-C6-NH22411422-49-4E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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