(S,R,S)-AHPC-PEG2-acid

Name: (S,R,S)-AHPC-PEG2-acid
Brand: MedChemExpress
SKU: HY-141016
Rating: 4.5 (1 reviews)

Cat. No.: HY-141016 Purity: 98.88%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

(S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-PEG2-acid Chemical Structure

CAS No. : 2172820-09-4

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote	Estimated Time of Arrival: December 31
100 mg	Get quote	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

(S,R,S)-AHPC-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

618.74

Formula

C₃₀H₄₂N₄O₈S

CAS No.

2172820-09-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CCOCCOCCC(O)=O)=O)=O)C[C@H](O)C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (161.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6162 mL	8.0809 mL	16.1619 mL
5 mM	0.3232 mL	1.6162 mL	3.2324 mL
10 mM	0.1616 mL	0.8081 mL	1.6162 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.88%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (252 KB) HNMR (271 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6162 mL	8.0809 mL	16.1619 mL	40.4047 mL
	5 mM	0.3232 mL	1.6162 mL	3.2324 mL	8.0809 mL
	10 mM	0.1616 mL	0.8081 mL	1.6162 mL	4.0405 mL
	15 mM	0.1077 mL	0.5387 mL	1.0775 mL	2.6936 mL
	20 mM	0.0808 mL	0.4040 mL	0.8081 mL	2.0202 mL
	25 mM	0.0646 mL	0.3232 mL	0.6465 mL	1.6162 mL
	30 mM	0.0539 mL	0.2694 mL	0.5387 mL	1.3468 mL
	40 mM	0.0404 mL	0.2020 mL	0.4040 mL	1.0101 mL
	50 mM	0.0323 mL	0.1616 mL	0.3232 mL	0.8081 mL
	60 mM	0.0269 mL	0.1347 mL	0.2694 mL	0.6734 mL
	80 mM	0.0202 mL	0.1010 mL	0.2020 mL	0.5051 mL
	100 mM	0.0162 mL	0.0808 mL	0.1616 mL	0.4040 mL