S49076 hydrochloride

Cat. No.: HY-12965A: FAQs
Data Sheet Handling Instructions

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S49076 hydrochloride is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC₅₀ values below 20 nM.

For research use only. We do not sell to patients.

S49076 hydrochloride Chemical Structure

CAS No. : 1265966-31-1

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Other In-stock Forms of S49076 hydrochloride:

S49076

Other Forms of S49076 hydrochloride:

S49076 In-stock

1 Publications Citing Use of MCE S49076 hydrochloride

•Nat Commun. 2019 Apr 18;10(1):1812 [Abstract]

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•Related Small Molecules:

•Related Proteins:

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

Biological Activity
Purity & Documentation
References
Customer Review

Description

S49076 hydrochloride is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC₅₀ values below 20 nM.

Molecular Weight

474.96

Formula

C₂₂H₂₃ClN₄O₄S

CAS No.

1265966-31-1

SMILES

O=C(N1CC2=CC3=C(NC(/C3=C\C4=CC(CN5CCOCC5)=CN4)=O)C=C2)SCC1=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : ≥ 31 mg/mL (65.27 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1054 mL	10.5272 mL	21.0544 mL
5 mM	0.4211 mL	2.1054 mL	4.2109 mL
10 mM	0.2105 mL	1.0527 mL	2.1054 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Burbridge MF, et al. S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab. Mol Cancer Ther. 2013 Sep;12(9):1749-62. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1054 mL	10.5272 mL	21.0544 mL	52.6360 mL
	5 mM	0.4211 mL	2.1054 mL	4.2109 mL	10.5272 mL
	10 mM	0.2105 mL	1.0527 mL	2.1054 mL	5.2636 mL
	15 mM	0.1404 mL	0.7018 mL	1.4036 mL	3.5091 mL
	20 mM	0.1053 mL	0.5264 mL	1.0527 mL	2.6318 mL
	25 mM	0.0842 mL	0.4211 mL	0.8422 mL	2.1054 mL
	30 mM	0.0702 mL	0.3509 mL	0.7018 mL	1.7545 mL
	40 mM	0.0526 mL	0.2632 mL	0.5264 mL	1.3159 mL
	50 mM	0.0421 mL	0.2105 mL	0.4211 mL	1.0527 mL
	60 mM	0.0351 mL	0.1755 mL	0.3509 mL	0.8773 mL